Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 17/20 | 0.59 |
| ▸ | PPARA | Q07869 | 17/20 | 0.59 |
| ▸ | PPARD | Q03181 | 4/20 | 0.59 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6555767 | 0.93 | PPARG (0.68) | PPARGPPARAPPARD | |
| SCHEMBL7004808 | 0.92 | PPARG (0.67) | PPARGPPARAPPARDPGRADORA3 | |
| Lithium SCHEMBL7004819 | 0.92 | PPARG (0.67) | PPARGPPARAPPARDPGRADORA3 | |
| SCHEMBL7006234 | 0.92 | PPARG (0.67) | PPARGPPARAPPARDPGRADORA3 | |
| Pimagedine SCHEMBL7532230 | 0.91 | PPARG (0.58) | PPARGPPARAPPARDPGRADORA3 | |
| Tromethamine SCHEMBL7004271 | 0.88 | PPARG (0.60) | PPARGPPARAPPARDPGRADORA3 | |
| Metformin SCHEMBL7006160 | 0.88 | PPARG (0.54) | PPARGPPARAPPARDPGRADORA3 | |
| SCHEMBL7006236 | 0.87 | PPARG (0.59) | PPARGPPARAPPARD | |
| Lithium Ion SCHEMBL7004812 | 0.87 | PPARG (0.59) | PPARGPPARAPPARD | |
| N-Benzylmethylamine SCHEMBL7002290 | 0.86 | PPARG (0.60) | PPARGPPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363913-A2 | SALTS OF PYRIMIDINE DERIVATIVES FOR USE AGAINST CORONARY HEART DISEASE AND ATHEROSCLEROSE | Dr. Reddy's Laboratories Ltd. (IN) | 2003-11-26 | — | — | EP | claimed |
| WO-2002062798-A2 | SALTS OF PYRIMIDINE DERIVATIVES FOR USE AGAINST CORONARY HEART DISEASE AND ATHEROSCLEROSE | DR. REDDY'S LABORATORIES LTD. (IN) | 2002-08-15 | — | — | WO | claimed |
| EP-1363913-A2 | SALTS OF PYRIMIDINE DERIVATIVES FOR USE AGAINST CORONARY HEART DISEASE AND ATHEROSCLEROSE | Dr. Reddy's Laboratories Ltd. (IN) | 2003-11-26 | — | — | EP | disclosed |
| WO-2002062798-A2 | SALTS OF PYRIMIDINE DERIVATIVES FOR USE AGAINST CORONARY HEART DISEASE AND ATHEROSCLEROSE | DR. REDDY'S LABORATORIES LTD. (IN) | 2002-08-15 | — | — | WO | disclosed |