Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | PPP1R15A | O75807 | 1/20 | 0.40 |
| ▸ | MELK | Q14680 | 1/20 | 0.40 |
| ▸ | PPP1R15B | Q5SWA1 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7008421 | 1.00 | KMT2A (0.52) | KMT2AMEN1AKR1C3TSHRAPEX1 | |
| SCHEMBL1627492 | 0.85 | AKR1C3 (0.57) | KMT2AMEN1AKR1C3APEX1ALDH1A1 | |
| SCHEMBL1627491 | 0.85 | AKR1C3 (0.57) | KMT2AMEN1AKR1C3APEX1ALDH1A1 | |
| SCHEMBL3958270 | 0.84 | AKR1C3 (0.46) | KMT2AMEN1AKR1C3TSHRAPEX1 | |
| SCHEMBL1805524 | 0.84 | AKR1C3 (0.46) | KMT2AMEN1AKR1C3TSHRAPEX1 | |
| SCHEMBL819819 | 0.83 | KMT2A (0.44) | KMT2AMEN1TSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL822890 | 0.83 | KMT2A (0.44) | KMT2AMEN1TSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL822823 | 0.80 | KMT2A (0.47) | KMT2AMEN1TSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL7820417 | 0.79 | AKR1C3 (0.53) | KMT2AMEN1AKR1C3TSHRAPEX1 | |
| SCHEMBL7820420 | 0.79 | AKR1C3 (0.53) | KMT2AMEN1AKR1C3TSHRAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |
| EP-1309551-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014273-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-02-21 | — | — | WO | disclosed |