SCHEMBL7008696

SCHEMBL7008696

S=CCc1cccc(Br)c1

nearest known ligand 0.50

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 3/20 0.50
IDO1 P14902 2/20 0.48
AGXT P21549 2/20 0.48
MAOB P27338 4/20 0.46
SMN1; SMN2 Q16637 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
MAOA P21397 1/20 0.40
HCAR2 Q8TDS4 1/20 0.40
PYCR1 P32322 1/20 0.40
CYP11B1 P15538 1/20 0.40
ADRA2C P18825 1/20 0.40
CYP11B2 P19099 1/20 0.40
KDM1A O60341 1/20 0.39
ALDH1A1 P00352 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4310219 0.80 IDO1 (0.55) TAAR1IDO1AGXTMAOBSMN1; SMN2
SCHEMBL689563 0.80 TAAR1 (0.52) TAAR1IDO1AGXTMAOBSMN1; SMN2
SCHEMBL6263676 0.78 TAAR1 (0.50) TAAR1IDO1AGXTMAOBSMN1; SMN2
SCHEMBL3185470 0.78 TAAR1 (0.50) TAAR1IDO1AGXTMAOBSMN1; SMN2
SCHEMBL30581261 0.78 TAAR1 (0.50) TAAR1IDO1AGXTMAOBSMN1; SMN2
SCHEMBL27744248 0.78 TAAR1 (0.55) TAAR1IDO1AGXTMAOBSMN1; SMN2
SCHEMBL27695225 0.75 TAAR1 (0.47) TAAR1IDO1AGXTMAOBSMN1; SMN2
SCHEMBL28351492 0.75 IDO1 (0.55) TAAR1IDO1AGXTMAOBSMN1; SMN2
SCHEMBL42450 0.75
SCHEMBL9216959 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114956933-A Marker containing isotope oxygen atom and preparation method and application thereof 清华大学 2022-08-30 CN disclosed
EP-1054857-B1 BIARYL-ACETIC ACID DERIVATIVES AND THEIR USE AS COX-2 INHIBITORS MERCK FROSST CANADA INC (CA) 2003-11-05 EP disclosed
EP-1054857-A1 BIARYL-ACETIC ACID DERIVATIVES AND THEIR USE AS COX-2 INHIBITORS Merck Frosst Canada & Co. (CA) 2000-11-29 EP disclosed
US-5994379-A Bisaryl COX-2 inhibiting compounds, compositions and methods of use MERCK FROSST CANADA, INC. (CA) 1999-11-30 US disclosed
WO-1999041224-A1 BIARYL-ACETIC ACID DERIVATIVES AND THEIR USE AS COX-2 INHIBITORS MERCK FROSST CANADA & CO. (CA) 1999-08-19 WO disclosed