Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 20/20 | 0.56 |
| ▸ | CCND1 | P24385 | 20/20 | 0.56 |
| ▸ | CCND2 | P30279 | 20/20 | 0.56 |
| ▸ | CCND3 | P30281 | 20/20 | 0.56 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.51 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.51 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.51 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.51 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29830539 | 1.00 | CDK4 (0.56) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL29830517 | 0.87 | CDK4 (0.53) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL29830317 | 0.83 | CDK4 (0.54) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL29830311 | 0.83 | CDK4 (0.44) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL29830387 | 0.81 | CDK4 (0.40) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL29830824 | 0.80 | CDK4 (0.42) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL30719007 | 0.80 | CYP1A2 (0.56) | CDK4CCND1CCND2CCND3 | |
| SCHEMBL29830646 | 0.80 | CDK4 (0.41) | CDK4CCND1CCND2CCND3CCNB2 | |
| SCHEMBL8328996 | 0.77 | CDK4 (0.48) | CDK4CCND1CCND2CCND3 | |
| SCHEMBL29542651 | 0.77 | CDK4 (0.48) | CDK4CCND1CCND2CCND3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307450-A2 | 2-(4-PYRDYL)AMINO-6-DIALKOXYPHENYL-PYRIDO(2.3-D)PYRIMIDIN-7-ONES | WARNER-LAMBERT COMPANY (US) | 2003-05-07 | — | — | EP | claimed |
| WO-2002012238-A2 | 2-(4-PYRIDYL)AMINO-6-DIALKOXYPHENYL-PYRIDO[2,3-d]PYRIMIDIN-7-ONES | WARNER-LAMBERT COMPANY (US) | 2002-02-14 | — | — | WO | claimed |