Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 7/20 | 0.52 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.52 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.52 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.52 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.52 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.52 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6412 | 0.88 | LPAR1 (0.40) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL14713 | 0.82 | LPAR1 (0.57) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL1619 | 0.81 | LPAR1 (0.58) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL7303 | 0.80 | CYP2A6 (0.38) | LPAR1MAPTKDM4ELPAR3SMN1; SMN2 | |
| SCHEMBL7139 | 0.78 | LPAR1 (0.55) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL1547 | 0.78 | LPAR1 (0.66) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL7008 | 0.77 | LPAR1 (0.45) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL3807 | 0.76 | LPAR1 (0.54) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL11148 | 0.76 | LPAR1 (0.54) | LPAR1ABCC3ABCC4ABCB11CYP2C8 | |
| SCHEMBL3633 | 0.75 | LPAR1 (0.64) | LPAR1ABCC3ABCC4ABCB11CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | claimed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | claimed |