Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.58 |
| ▸ | IGF1R | P08069 | 1/20 | 0.57 |
| ▸ | MGAM | O43451 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | SI | P14410 | 1/20 | 0.57 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.57 |
| ▸ | PIM1 | P11309 | 1/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.55 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.55 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 6/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | ESRRA | P11474 | 1/20 | 0.51 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6355409 | 1.00 | MEN1 (0.68) | MEN1KMT2ACISD1IGF1RMGAM | |
| SCHEMBL7013434 | 0.86 | HPGD (0.62) | PIM1PIM2HPGDPTPN1 | |
| SCHEMBL5935568 | 0.86 | HPGD (0.62) | PIM1PIM2HPGDPTPN1 | |
| SCHEMBL6357262 | 0.85 | HPGD (0.61) | PIM1PIM2HPGDPTPN1 | |
| SCHEMBL6357256 | 0.85 | HPGD (0.61) | PIM1PIM2HPGDPTPN1 | |
| SCHEMBL5935564 | 0.84 | KMT2A (0.47) | MEN1KMT2ACISD1HPGDPTPN1 | |
| SCHEMBL5935567 | 0.83 | KMT2A (0.46) | MEN1KMT2ACISD1GAAHPGD | |
| SCHEMBL5935621 | 0.83 | KDM4E (0.54) | MEN1KMT2A | |
| SCHEMBL5508722 | 0.82 | MEN1 (1.00) | MEN1KMT2ACISD1IGF1RMGAM | |
| SCHEMBL5508719 | 0.82 | MEN1 (1.00) | MEN1KMT2ACISD1IGF1RMGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958296-B1 | HETEROCYCLIC COMPOUNDS PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THE TREATMENT OF DIABETES AND RELATED DISEASES | REDDYS LAB LTD DR (IN) | 2003-07-30 | — | — | EP | claimed |