Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 2/20 | 0.88 |
| ▸ | LCK | P06239 | 1/20 | 0.88 |
| ▸ | FYN | P06241 | 1/20 | 0.88 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | THPO | P40225 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL337441 | 1.00 | — | — | |
| Acetic Acid SCHEMBL28198977 | 0.94 | — | — | |
| Acetic Acid SCHEMBL5838543 | 0.94 | — | — | |
| Acetic Acid SCHEMBL27413126 | 0.94 | FFAR3 (0.78) | FFAR3LCKFYNLMNATSHR | |
| Acetic Acid SCHEMBL9413749 | 0.94 | FFAR3 (0.78) | FFAR3LCKFYNLMNATSHR | |
| Acetic Acid SCHEMBL28403497 | 0.94 | — | — | |
| Acetic Acid SCHEMBL94374 | 0.94 | — | — | |
| Acetic Acid SCHEMBL10534135 | 0.94 | — | — | |
| Acetic Acid SCHEMBL2944890 | 0.94 | — | — | |
| Acetic Acid SCHEMBL28093882 | 0.94 | FFAR3 (0.78) | FFAR3LCKFYNLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5902873-A | CONTAINING A TIATANIUM OR ZIRONIUM COMPOUND WITH A LANTHANIDE COMPOUND | GENERAL ELECTRIC COMPANY (US) | 1999-05-11 | — | — | US | claimed |
| EP-0909774-B1 | Catalyst composition for the preparation of polyesters and related processes | GEN ELECTRIC (US) | 2003-01-08 | — | — | EP | disclosed |
| US-5902873-A | CONTAINING A TIATANIUM OR ZIRONIUM COMPOUND WITH A LANTHANIDE COMPOUND | GENERAL ELECTRIC COMPANY (US) | 1999-05-11 | — | — | US | disclosed |
| EP-0909774-A1 | Catalyst composition for the preparation of polyesters and related processes | GENERAL ELECTRIC COMPANY (US) | 1999-04-21 | — | — | EP | disclosed |
| US-4152351-A | USING MANAGANESE OR LANTHANIDE ADJUVANTS ON CATALYSTS | PHILLIPS PETROLEUM COMPANY (US) | 1979-05-01 | — | — | US | disclosed |