Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 14/20 | 0.73 |
| ▸ | TEK | Q02763 | 13/20 | 0.73 |
| ▸ | KDR | P35968 | 10/20 | 0.73 |
| ▸ | SRC | P12931 | 10/20 | 0.73 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.47 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | RGS12 | O14924 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GMNN | O75496 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | LYN | P07948 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7011631 | 0.93 | LCK (0.65) | LCKTEKKDRSRCEGFR | |
| SCHEMBL7008533 | 0.92 | KDR (0.64) | LCKTEKKDRSRCEGFR | |
| SCHEMBL7009424 | 0.90 | TEK (0.59) | LCKTEKKDRSRCEGFR | |
| SCHEMBL7003841 | 0.88 | LCK (0.74) | LCKTEKKDRSRCEGFR | |
| SCHEMBL7008614 | 0.88 | LCK (0.74) | LCKTEKKDRSRCEGFR | |
| SCHEMBL7009027 | 0.87 | LCK (0.72) | LCKTEKKDRSRCEGFR | |
| SCHEMBL6861193 | 0.85 | LCK (1.00) | LCKTEKKDRSRCEGFR | |
| SCHEMBL7005544 | 0.84 | LCK (0.68) | LCKTEKKDRSRCEGFR | |
| SCHEMBL7005163 | 0.84 | SRC (0.81) | LCKTEKKDRSRCEGFR | |
| SCHEMBL7006912 | 0.83 | KDR (0.63) | LCKTEKKDRSRCEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970084-B1 | PYRROLO 2,3D]PYRIMIDINES AND THEIR USE AS TYROSINE KINASE INHIBITORS | BASF AG (DE) | 2003-06-04 | — | — | EP | disclosed |
| US-6001839-A | Substituted 4-amino-7H-pyrrolo [2,3,-d]-pyrimidines as PTK inhibitors | BASF AKTIENGESELLSCHAFT (DE) | 1999-12-14 | — | — | US | disclosed |