SCHEMBL7010373

SCHEMBL7010373

COc1cc(F)c(N)cc1-n1cc(C(=O)O)c(=O)c2cc(F)c(F)c(Cl)c21

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TOP1 P11387 8/20 0.50
CYP3A4 P08684 2/20 0.42
CYP2C9 P11712 2/20 0.42
PIM1 P11309 2/20 0.42
TOP2A P11388 9/20 0.41
ALDH1A1 P00352 2/20 0.41
POLB P06746 2/20 0.41
KDM4E B2RXH2 1/20 0.41
HSP90AA1 P07900 1/20 0.41
RXFP1 Q9HBX9 1/20 0.41
TOP2B Q02880 3/20 0.37
CHRM2 P08172 1/20 0.37
CHRM1 P11229 1/20 0.37
OPRM1 P35372 1/20 0.37
OPRD1 P41143 1/20 0.37
MEN1 O00255 1/20 0.37
LMNA P02545 1/20 0.37
KMT2A Q03164 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7006508 0.88 TOP1 (0.54) TOP1CYP3A4CYP2C9PIM1TOP2A
SCHEMBL7007852 0.88 TOP1 (0.52) TOP1CYP3A4CYP2C9PIM1TOP2A
SCHEMBL7005195 0.87 TOP1 (0.53) TOP1CYP3A4CYP2C9PIM1TOP2A
SCHEMBL7005286 0.85 TOP1 (0.52) TOP1CYP3A4CYP2C9PIM1TOP2A
SCHEMBL7009803 0.85 TOP1 (0.45) TOP1CYP3A4CYP2C9PIM1TOP2A
SCHEMBL7010547 0.84 CYP3A4 (0.64) TOP1CYP3A4CYP2C9TOP2AALDH1A1
SCHEMBL7010330 0.84 TOP1 (0.52) TOP1CYP3A4CYP2C9PIM1TOP2A
SCHEMBL19728759 0.84 TOP1 (0.50) TOP1CYP3A4CYP2C9PIM1TOP2A
SCHEMBL7007269 0.83 TOP1 (0.51) TOP1CYP3A4CYP2C9PIM1TOP2A
SCHEMBL6578430 0.81 TOP1 (0.52) TOP1CYP3A4CYP2C9PIM1TOP2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0787720-B1 PYRIDONECARBOXYLATE DERIVATIVE OR SALT THEREOF AND ANTIBACTERIAL CONTAINING THE SAME AS ACTIVE INGREDIENT WAKUNAGA SEIYAKU KK (JP) 2003-07-16 EP disclosed
US-5910498-A NOVEL COMPOUNDS HAVING REDUCED CYTOTOXICITY, PHOTOTOXICITY; TREATING BACTERIAL AND VIRAL INFECTIONS WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1999-06-08 US disclosed
EP-0787720-A1 NOVEL PYRIDONECARBOXYLATE DERIVATIVE OR SALT THEREOF AND ANTIBACTERIAL CONTAINING THE SAME AS ACTIVE INGREDIENT WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1997-08-06 EP disclosed