SCHEMBL7010952

SCHEMBL7010952

COc1c(N2CC(N)C2)c(F)cc2c(=O)c(C(=O)O)cn(-c3cc(N)c(F)cc3F)c12

nearest known ligand 0.54

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.54
CYP2C9 P11712 1/20 0.54
TOP1 P11387 5/20 0.52
KCNH2 Q12809 3/20 0.51
TOP2A P11388 8/20 0.51
TOP2B Q02880 5/20 0.50
KDM4E B2RXH2 2/20 0.49
ALDH1A1 P00352 2/20 0.49
HPGD P15428 2/20 0.49
HSD17B10 Q99714 2/20 0.49
POLB P06746 1/20 0.49
PRKD3 O94806 1/20 0.49
ALOX15 P16050 1/20 0.49
OPRM1 P35372 1/20 0.49
CLK2 P49760 1/20 0.49
CLK4 Q9HAZ1 1/20 0.49
TDP1 Q9NUW8 1/20 0.49
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19729434 0.91 TOP1 (0.51) CYP3A4CYP2C9TOP1KCNH2TOP2A
SCHEMBL7008959 0.90 CYP3A4 (0.58) CYP3A4CYP2C9TOP1TOP2ATOP2B
SCHEMBL6580734 0.88 CYP3A4 (0.56) CYP3A4CYP2C9TOP1KCNH2TOP2A
SCHEMBL7004804 0.86 CYP3A4 (0.71) CYP3A4CYP2C9TOP1TOP2ATOP2B
SCHEMBL7007387 0.86 CYP3A4 (0.56) CYP3A4CYP2C9TOP1TOP2ATOP2B
SCHEMBL19728720 0.84 KCNH2 (0.50) CYP3A4CYP2C9TOP1KCNH2TOP2A
SCHEMBL7010547 0.84 CYP3A4 (0.64) CYP3A4CYP2C9TOP1TOP2ATOP2B
SCHEMBL7013204 0.84 KDM4E (0.52) CYP3A4CYP2C9TOP1TOP2ATOP2B
SCHEMBL7009566 0.84 TOP1 (0.52) CYP3A4CYP2C9TOP1KCNH2TOP2A
SCHEMBL7012569 0.84 CYP3A4 (0.56) CYP3A4CYP2C9TOP1TOP2ATOP2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0787720-B1 PYRIDONECARBOXYLATE DERIVATIVE OR SALT THEREOF AND ANTIBACTERIAL CONTAINING THE SAME AS ACTIVE INGREDIENT WAKUNAGA SEIYAKU KK (JP) 2003-07-16 EP disclosed
US-5910498-A NOVEL COMPOUNDS HAVING REDUCED CYTOTOXICITY, PHOTOTOXICITY; TREATING BACTERIAL AND VIRAL INFECTIONS WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1999-06-08 US disclosed
EP-0787720-A1 NOVEL PYRIDONECARBOXYLATE DERIVATIVE OR SALT THEREOF AND ANTIBACTERIAL CONTAINING THE SAME AS ACTIVE INGREDIENT WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) 1997-08-06 EP disclosed