Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 4/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 2/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | PRKX | P51817 | 2/20 | 0.40 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.40 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.40 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.40 |
| ▸ | CSNK1G1 | Q9HCP0 | 2/20 | 0.40 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8639166 | 0.76 | CHEK1 (0.47) | PLK1CHEK1CDC7PLK4DAPK3 | |
| SCHEMBL7887005 | 0.76 | CHEK1 (0.47) | PLK1CHEK1CDC7PLK4DAPK3 | |
| SCHEMBL4305804 | 0.72 | PIK3CA (0.56) | GSK3BHDAC1HDAC8CNR2NLRP3 | |
| SCHEMBL7013832 | 0.71 | PLK1 (0.47) | PLK1CHEK1CDC7PLK4DAPK3 | |
| SCHEMBL7011583 | 0.70 | PLK1 (0.42) | PLK1CHEK1CDC7PLK4DAPK3 | |
| SCHEMBL4657783 | 0.67 | PIK3CA (0.50) | GSK3BHDAC1HDAC8CNR2NLRP3 | |
| SCHEMBL5161111 | 0.67 | CNR2 (0.58) | HDAC1HDAC8CNR2PIK3CA | |
| SCHEMBL7012005 | 0.66 | PLK1 (0.47) | PLK1CHEK1CDC7PLK4DAPK3 | |
| SCHEMBL7534399 | 0.66 | PLK1 (0.40) | PLK1CHEK1CDC7PLK4DAPK3 | |
| SCHEMBL10206351 | 0.65 | PIK3CA (0.49) | HDAC1HDAC8CNR2NLRP3HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003529532-A | — | — | 2003-10-07 | — | — | JP | claimed |
| EP-1135365-A1 | 4-3-SUBSTITUTED-AMINO-CYCLOBUT-3-ENE-1,2-DIONES AND USE FOR INFLUENCING SMOOTH MUSCLE CONTRACTION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-09-26 | — | — | EP | claimed |
| WO-2000034230-A1 | 4-3-SUBSTITUTED-AMINO-CYCLOBUT-3-ENE-1,2-DIONES AND USE FOR INFLUENCING SMOOTH MUSCLE CONTRACTION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-06-15 | — | — | WO | claimed |