Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 15/20 | 0.68 |
| ▸ | PLA2G2A | P14555 | 5/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7007223 | 0.90 | PLA2G1B (0.84) | PLA2G1BPLA2G2A | |
| SCHEMBL7011658 | 0.87 | PLA2G1B (0.79) | PLA2G1BPLA2G2A | |
| SCHEMBL7007915 | 0.85 | PLA2G1B (0.84) | PLA2G1BPLA2G2A | |
| SCHEMBL7006670 | 0.83 | PLA2G1B (0.63) | PLA2G1BPLA2G2A | |
| SCHEMBL7006200 | 0.81 | PLA2G1B (1.00) | PLA2G1BPLA2G2A | |
| SCHEMBL7011105 | 0.80 | PLA2G1B (0.84) | PLA2G1BPLA2G2A | |
| SCHEMBL7013748 | 0.79 | PLA2G1B (0.68) | PLA2G1BPLA2G2A | |
| SCHEMBL7015348 | 0.78 | PLA2G1B (0.57) | PLA2G1BPLA2G2A | |
| SCHEMBL7015616 | 0.78 | PLA2G1B (0.93) | PLA2G1BPLA2G2A | |
| SCHEMBL7007898 | 0.77 | PLA2G1B (0.65) | PLA2G1BPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645976-B1 | Nonpancreatic secretory phospholipase (sPLA2) supressors such as 2-(3-Benzyl-8-hydroxy-2-ethylindolizin-1-yl)acetamide, administered to control release of fatty acid and prevent the arachidonic acid cascade; septic shock | ELI LILLY AND COMPANY | 2003-11-11 | — | — | US | disclosed |
| EP-0772596-B1 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-10-01 | — | — | EP | disclosed |
| WO-1996003383-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-08 | — | — | WO | disclosed |