Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 7/20 | 0.36 |
| ▸ | MEN1 | O00255 | 7/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.36 |
| ▸ | RGS12 | O14924 | 6/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7012468 | 1.00 | USP2 (0.36) | USP2MEN1KMT2ARGS12KDM4E | |
| SCHEMBL7258493 | 0.86 | USP2 (0.38) | USP2MEN1KMT2ARGS12KDM4E | |
| SCHEMBL7105873 | 0.86 | USP2 (0.38) | USP2MEN1KMT2ARGS12KDM4E | |
| SCHEMBL7014592 | 0.79 | FEN1 (0.35) | USP2MEN1KMT2ARGS12KDM4E | |
| SCHEMBL7014590 | 0.79 | FEN1 (0.35) | USP2MEN1KMT2ARGS12KDM4E | |
| SCHEMBL7020404 | 0.76 | KDM4E (0.45) | KDM4E | |
| SCHEMBL7020408 | 0.76 | KDM4E (0.45) | KDM4E | |
| SCHEMBL7017348 | 0.74 | USP2 (0.35) | USP2MEN1KMT2ARGS12KDM4E | |
| SCHEMBL7017351 | 0.74 | USP2 (0.35) | USP2MEN1KMT2ARGS12KDM4E | |
| SCHEMBL7022158 | 0.72 | USP2 (0.38) | USP2MEN1KMT2ARGS12KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1357114-A1 | Substituted pyrimidin-2,4(1H,3H)-diones as inhibitors of Matrix Metalloproteinases (MMP) | IBFB GmbH Privates Institut für biomedizinische Forschung und Beratung (DE) | 2003-10-29 | — | — | EP | disclosed |