Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 7/20 | 0.56 |
| ▸ | TOP2B | Q02880 | 7/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7006628 | 0.99 | TOP2A (0.56) | TOP2ATOP2BKDM4EALDH1A1LMNA | |
| SCHEMBL7011800 | 0.91 | KDM4E (0.47) | TOP2ATOP2BKDM4EALDH1A1LMNA | |
| SCHEMBL4998670 | 0.88 | TOP2A (0.52) | TOP2ATOP2BKDM4EALDH1A1LMNA | |
| SCHEMBL8323622 | 0.88 | KDM4E (0.43) | TOP2ATOP2BKDM4EALDH1A1LMNA | |
| SCHEMBL7013592 | 0.88 | KDM4E (0.43) | TOP2ATOP2BKDM4EALDH1A1LMNA | |
| SCHEMBL7006088 | 0.87 | TOP2A (0.56) | TOP2ATOP2BKDM4EALDH1A1LMNA | |
| SCHEMBL7009663 | 0.85 | TOP2A (0.50) | TOP2ATOP2BKDM4EALDH1A1LMNA | |
| SCHEMBL4990107 | 0.85 | KDM4E (0.50) | TOP2ATOP2BKDM4EALDH1A1LMNA | |
| SCHEMBL7007516 | 0.85 | KDM4E (0.52) | TOP2ATOP2BKDM4EALDH1A1LMNA | |
| SCHEMBL7005796 | 0.84 | TOP2A (0.51) | TOP2ATOP2BKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775702-B1 | NOVEL QUINOLONE- OR NAPHTHYRIDONECARBOXYLIC ACID DERIVATIVE OR SALT THEREOF | TOYAMA CHEMICAL CO LTD (JP) | 2003-07-23 | — | — | EP | disclosed |
| US-5935952-A | ANTIBACTERIAL AGENT | TOYAMA CHEMICAL CO., LTD. (JP) | 1999-08-10 | — | — | US | disclosed |
| EP-0775702-A1 | NOVEL QUINOLONE- OR NAPHTHYRIDONECARBOXYLIC ACID DERIVATIVE OR SALT THEREOF | TOYAMA CHEMICAL CO., LTD. (JP) | 1997-05-28 | — | — | EP | disclosed |