Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 14/20 | 0.57 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013950 | 0.87 | PLA2G1B (0.57) | PLA2G1BPLA2G2A | |
| SCHEMBL7012842 | 0.75 | PLA2G1B (0.81) | PLA2G1BPLA2G2A | |
| SCHEMBL7010695 | 0.75 | PLA2G1B (0.72) | PLA2G1BPLA2G2A | |
| SCHEMBL7012897 | 0.74 | PLA2G1B (0.71) | PLA2G1BPLA2G2A | |
| SCHEMBL7006820 | 0.73 | PLA2G1B (1.00) | PLA2G1BPLA2G2A | |
| SCHEMBL7011894 | 0.73 | PLA2G1B (1.00) | PLA2G1BPLA2G2A | |
| SCHEMBL7010871 | 0.72 | PLA2G1B (0.84) | PLA2G1B | |
| SCHEMBL7009236 | 0.72 | PLA2G1B (0.84) | PLA2G1B | |
| SCHEMBL7012314 | 0.72 | ADORA2A (0.37) | PLA2G1BPLA2G2AMTNR1AMTNR1B | |
| SCHEMBL7187172 | 0.71 | PLA2G1B (0.72) | PLA2G1BPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645976-B1 | Nonpancreatic secretory phospholipase (sPLA2) supressors such as 2-(3-Benzyl-8-hydroxy-2-ethylindolizin-1-yl)acetamide, administered to control release of fatty acid and prevent the arachidonic acid cascade; septic shock | ELI LILLY AND COMPANY | 2003-11-11 | — | — | US | disclosed |
| EP-0772596-B1 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-10-01 | — | — | EP | disclosed |
| EP-0772596-A4 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 1999-01-13 | — | — | EP | disclosed |
| EP-0772596-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003383-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-08 | — | — | WO | disclosed |