Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.54 |
| ▸ | PDE1A | P54750 | 7/20 | 0.51 |
| ▸ | PDE1B | Q01064 | 7/20 | 0.51 |
| ▸ | PDE1C | Q14123 | 7/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6305768 | 0.93 | PDE5A (0.62) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL6312468 | 0.91 | PDE5A (0.59) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL6305530 | 0.88 | PDE5A (0.61) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL7165849 | 0.86 | PDE5A (0.59) | PDE5APDE3BPDE3A | |
| SCHEMBL6305113 | 0.85 | PDE5A (0.58) | PDE5APDE3BPDE3A | |
| SCHEMBL6308305 | 0.84 | PDE5A (0.69) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL6306670 | 0.84 | PDE5A (0.64) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL6305534 | 0.84 | PDE5A (0.62) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL6312785 | 0.83 | PDE5A (0.57) | PDE5APDE3BPDE3A | |
| SCHEMBL6306675 | 0.82 | PDE5A (0.59) | PDE5APDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1286997-A1 | 6-PHENYLPYRROLOPYRIMIDINEDIONE DERIVATIVES | Almirall Prodesfarma, S.A. (ES) | 2003-03-05 | — | — | EP | disclosed |
| WO-2001094350-A1 | 6-PHENYLPYRROLOPYRIMIDINEDIONE DERIVATIVES | ALMIRALL PRODESFARMA S.A. (ES) | 2001-12-13 | — | — | WO | disclosed |