Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 6/20 | 0.31 |
| ▸ | KDR | P35968 | 6/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | LIPE | Q05469 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7015651 | 0.91 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL7013469 | 0.90 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DEGFR | |
| SCHEMBL7019218 | 0.88 | PDE4B (0.49) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7015836 | 0.86 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7019362 | 0.85 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7021594 | 0.81 | PDE4D (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7019051 | 0.80 | PDE4B (0.47) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7015621 | 0.79 | PDE4D (0.49) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7020167 | 0.79 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL7021808 | 0.78 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086106-B1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | DARWIN DISCOVERY LTD (GB) | 2003-08-20 | — | — | EP | claimed |