Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5764760 | 0.89 | HTT (0.67) | NPC1RAB9AHSP90AA1SMN1; SMN2KMT2A | |
| SCHEMBL5764587 | 0.84 | NPC1 (0.52) | NPC1RAB9AHSP90AA1SMN1; SMN2KMT2A | |
| SCHEMBL5763025 | 0.77 | SMN1; SMN2 (0.51) | NPC1RAB9AHSP90AA1SMN1; SMN2KMT2A | |
| SCHEMBL2651977 | 0.77 | HTT (0.71) | NPC1RAB9AHSP90AA1SMN1; SMN2KMT2A | |
| SCHEMBL1934735 | 0.76 | NPC1 (0.48) | NPC1RAB9AHSP90AA1SMN1; SMN2KMT2A | |
| SCHEMBL901472 | 0.74 | TDP1 (0.72) | NPC1RAB9ASMN1; SMN2KMT2AHTT | |
| SCHEMBL4257456 | 0.73 | KMT2A (0.62) | NPC1RAB9AHSP90AA1SMN1; SMN2KMT2A | |
| SCHEMBL2652982 | 0.72 | HTT (0.46) | NPC1RAB9AHSP90AA1SMN1; SMN2KMT2A | |
| SCHEMBL18263634 | 0.71 | HTT (0.54) | NPC1RAB9AHSP90AA1KMT2AHTT | |
| SCHEMBL5765557 | 0.71 | HTT (0.61) | NPC1RAB9AHSP90AA1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1334972-A1 | Non-peptide compounds affecting the action of gonadotropin-releasing hormone (GnRH) | PFIZER INC. (US) | 2003-08-13 | — | — | EP | disclosed |