Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | ALDH3A1 | P30838 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7012419 | 1.00 | KMT2A (0.50) | KMT2AMAPTLMNASMN1; SMN2HTT | |
| SCHEMBL7018740 | 1.00 | KMT2A (0.50) | KMT2AMAPTLMNASMN1; SMN2HTT | |
| SCHEMBL1625587 | 0.82 | KMT2A (0.61) | KMT2AMAPTLMNASMN1; SMN2HTT | |
| SCHEMBL1626173 | 0.82 | KMT2A (0.61) | KMT2AMAPTLMNASMN1; SMN2HTT | |
| SCHEMBL1626319 | 0.82 | KMT2A (0.61) | KMT2AMAPTLMNASMN1; SMN2HTT | |
| SCHEMBL7015453 | 0.82 | TDP1 (0.45) | KMT2AMAPTLMNASMN1; SMN2HTT | |
| SCHEMBL6384045 | 0.81 | KMT2A (0.50) | KMT2AMAPTLMNASMN1; SMN2HTT | |
| SCHEMBL28008746 | 0.81 | KMT2A (0.61) | KMT2AMAPTLMNASMN1; SMN2HTT | |
| SCHEMBL6386479 | 0.80 | GAA (0.40) | KMT2AMAPTLMNASMN1; SMN2HTT | |
| SCHEMBL6387368 | 0.80 | GAA (0.40) | KMT2AMAPTLMNASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326606-A2 | EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS | PFIZER PHARMACEUTICALS INC. (JP) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002032422-A2 | EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS | PFIZER PHARMACEUTICALS INC. (JP) | 2002-04-25 | — | — | WO | disclosed |