Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30648848 | 0.80 | SMN1; SMN2 (0.56) | SMN1; SMN2POLBGAACYP1A2KMT2A | |
| SCHEMBL2681134 | 0.80 | SMN1; SMN2 (0.56) | SMN1; SMN2POLBGAACYP1A2KMT2A | |
| SCHEMBL9794274 | 0.78 | SMN1; SMN2 (0.53) | SMN1; SMN2POLBGAACYP1A2KMT2A | |
| Hydrochloric Acid SCHEMBL6085776 | 0.78 | POLB (0.43) | SMN1; SMN2POLBGAACYP1A2KMT2A | |
| SCHEMBL5094621 | 0.77 | DPP4 (0.54) | SMN1; SMN2POLBGAACYP1A2KMT2A | |
| Oxalic Acid SCHEMBL7421984 | 0.76 | SMN1; SMN2 (0.57) | SMN1; SMN2POLBGAACYP1A2KMT2A | |
| SCHEMBL7023016 | 0.75 | SMN1; SMN2 (0.50) | SMN1; SMN2POLBGAACYP1A2KMT2A | |
| Hydrochloric Acid SCHEMBL5089373 | 0.74 | POLB (0.42) | SMN1; SMN2POLBGAACYP1A2KMT2A | |
| SCHEMBL5091651 | 0.73 | SMN1; SMN2 (0.53) | SMN1; SMN2POLBGAACYP1A2KMT2A | |
| SCHEMBL9143702 | 0.72 | SMN1; SMN2 (0.63) | SMN1; SMN2POLBGAACYP1A2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |