Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.53 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.43 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.43 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.43 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.43 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.43 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.43 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6223751 | 0.90 | KDR (0.49) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL6229719 | 0.90 | KDR (0.51) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL6223944 | 0.88 | KDR (0.62) | KDRCITMAP3K7RIPK2STK10 | |
| SCHEMBL6224462 | 0.85 | PDPK1 (0.44) | KDRPDPK1ALDH1A1KDM4EGAA | |
| SCHEMBL6223556 | 0.85 | KDR (0.58) | KDRALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL7012450 | 0.83 | KDR (0.59) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL6105755 | 0.83 | KDR (0.59) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL6224503 | 0.83 | KDR (0.51) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL6103553 | 0.81 | KDR (0.55) | KDRTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL5265455 | 0.79 | RXFP1 (0.41) | KDRTUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358161-A2 | N-PYRIDYL CARBOXAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Amgen Inc. (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002055501-A2 | N-PYRIDYL CARBOXAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AMGEN INC (US) | 2002-07-18 | — | — | WO | disclosed |