Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 19/20 | 0.85 |
| ▸ | HTR1B | P28222 | 16/20 | 0.85 |
| ▸ | HTR1F | P30939 | 6/20 | 0.85 |
| ▸ | HTR1A | P08908 | 5/20 | 0.85 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.68 |
| ▸ | DRD2 | P14416 | 1/20 | 0.68 |
| ▸ | HTR2A | P28223 | 1/20 | 0.61 |
| ▸ | HTR2C | P28335 | 1/20 | 0.61 |
| ▸ | HTR1E | P28566 | 1/20 | 0.61 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6911508 | 0.92 | HTR1D (1.00) | HTR1DHTR1BHTR1FHTR1ACHRM2 | |
| Hydrochloric Acid SCHEMBL8604274 | 0.91 | HTR1D (0.98) | HTR1DHTR1BHTR1FHTR1ACHRM2 | |
| Fumaric Acid SCHEMBL7485328 | 0.87 | HTR1D (0.89) | HTR1DHTR1BHTR1FHTR1ACHRM2 | |
| Fumaric Acid SCHEMBL7485333 | 0.87 | HTR1D (0.89) | HTR1DHTR1BHTR1FHTR1ACHRM2 | |
| SCHEMBL7483506 | 0.87 | HTR1D (0.79) | HTR1DHTR1BHTR1FHTR1ACHRM2 | |
| SCHEMBL7842102 | 0.85 | HTR1D (0.64) | HTR1DHTR1BHTR1FHTR1A | |
| SCHEMBL7009508 | 0.85 | HTR1D (0.83) | HTR1DHTR1BHTR1FHTR1A | |
| SCHEMBL7484191 | 0.84 | HTR1D (0.81) | HTR1DHTR1BHTR1FHTR1ACHRM2 | |
| SCHEMBL7482014 | 0.83 | HTR1D (0.83) | HTR1DHTR1BHTR1FHTR1ACHRM2 | |
| SCHEMBL7480604 | 0.83 | HTR1D (0.83) | HTR1DHTR1BHTR1FHTR1ACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089993-B1 | 5-HT1F AGONISTS | LILLY CO ELI (US) | 2003-10-22 | — | — | EP | disclosed |
| US-6358972-B1 | FOR THERAPY OF MIGRAINE | ELI LILLY AND COMPANY | 2002-03-19 | — | — | US | disclosed |