Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 20/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7015420 | 0.92 | PLA2G1B (0.85) | PLA2G1B | |
| SCHEMBL7006656 | 0.92 | PLA2G1B (0.84) | PLA2G1B | |
| SCHEMBL5892138 | 0.89 | PLA2G1B (1.00) | PLA2G1B | |
| SCHEMBL7012847 | 0.85 | PLA2G1B (1.00) | PLA2G1B | |
| SCHEMBL7006587 | 0.84 | PLA2G1B (0.98) | PLA2G1B | |
| SCHEMBL7011907 | 0.84 | PLA2G1B (0.73) | PLA2G1B | |
| SCHEMBL7018369 | 0.83 | PLA2G1B (1.00) | PLA2G1B | |
| SCHEMBL8323100 | 0.83 | PLA2G1B (0.83) | PLA2G1B | |
| SCHEMBL5892148 | 0.82 | PLA2G1B (1.00) | PLA2G1B | |
| SCHEMBL7047797 | 0.81 | PLA2G1B (0.94) | PLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6645976-B1 | Nonpancreatic secretory phospholipase (sPLA2) supressors such as 2-(3-Benzyl-8-hydroxy-2-ethylindolizin-1-yl)acetamide, administered to control release of fatty acid and prevent the arachidonic acid cascade; septic shock | ELI LILLY AND COMPANY | 2003-11-11 | — | — | US | disclosed |
| EP-0772596-B1 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-10-01 | — | — | EP | disclosed |