Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.30 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7020260 | 0.83 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7017625 | 0.73 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7408555 | 0.73 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7011850 | 0.73 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7010243 | 0.70 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7014097 | 0.69 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7015027 | 0.69 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7014220 | 0.69 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7015746 | 0.68 | PDE4A (0.39) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7018885 | 0.68 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086106-B1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | DARWIN DISCOVERY LTD (GB) | 2003-08-20 | — | — | EP | claimed |
| EP-1086106-A1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | Darwin Discovery Limited (GB) | 2001-03-28 | — | — | EP | claimed |
| US-6169090-B1 | FOR INHIBITION OF PHOSPHODIESTERASE IV | DARWIN DISCOVERY, LTD. (GB) | 2001-01-02 | — | — | US | claimed |
| WO-1999064423-A1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | DARWIN DISCOVERY LIMITED (GB) | 1999-12-16 | — | — | WO | claimed |
| EP-1086106-B1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | DARWIN DISCOVERY LTD (GB) | 2003-08-20 | — | — | EP | disclosed |
| EP-1086106-A1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | Darwin Discovery Limited (GB) | 2001-03-28 | — | — | EP | disclosed |
| US-6169090-B1 | FOR INHIBITION OF PHOSPHODIESTERASE IV | DARWIN DISCOVERY, LTD. (GB) | 2001-01-02 | — | — | US | disclosed |
| WO-1999064423-A1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | DARWIN DISCOVERY LIMITED (GB) | 1999-12-16 | — | — | WO | disclosed |