Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 13/20 | 0.60 |
| ▸ | MKNK1 | Q9BUB5 | 12/20 | 0.60 |
| ▸ | LCK | P06239 | 2/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | HRH2 | P25021 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | HTR5A | P47898 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | OGA | O60502 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7018020 | 0.96 | MKNK2 (0.60) | MKNK2MKNK1LCKADRA2BADRA2C | |
| SCHEMBL7571233 | 0.88 | MKNK1 (0.60) | MKNK2MKNK1LCKADRA2BADRA2C | |
| SCHEMBL7498408 | 0.86 | MKNK1 (0.60) | MKNK2MKNK1LCKADRA2BADRA2C | |
| SCHEMBL7501973 | 0.85 | MKNK2 (0.67) | MKNK2MKNK1LCKADRA2BADRA2C | |
| SCHEMBL7504052 | 0.85 | MKNK1 (0.67) | MKNK2MKNK1LCKADRA2BADRA2C | |
| SCHEMBL7025681 | 0.82 | MKNK1 (0.87) | MKNK2MKNK1LCK | |
| SCHEMBL7505082 | 0.82 | MKNK1 (0.60) | MKNK2MKNK1LCKADRA2BADRA2C | |
| SCHEMBL7025399 | 0.81 | MKNK1 (0.68) | MKNK2MKNK1LCKADRA2BADRA2C | |
| SCHEMBL7502076 | 0.81 | MKNK1 (0.62) | MKNK2MKNK1LCKADRA2BADRA2C | |
| SCHEMBL7503206 | 0.81 | MKNK2 (0.62) | MKNK2MKNK1LCKADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-B1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2003-11-12 | — | — | EP | disclosed |
| US-6498165-B1 | PYRIMIDINE COMPOUNDS; PROPHYLAXIS AND TREATMENT OF SUCH AS IMMUNE DISEASES, HYPERPROLIFERATIVE DISORDERS, CANCER, ANGIOGENSIS, ATHEROSCELEROSIS, GRAFT REJECTION, RHEUMATOID ARTHRITIS, PSORIASIS | MERCK & CO., INC. | 2002-12-24 | — | — | US | disclosed |
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |