Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.42 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.42 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.42 |
| ▸ | AVPR2 | P30518 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7017226 | 0.89 | AVPR1A (0.45) | AVPR1AAVPR1BAVPR2MEN1KMT2A | |
| SCHEMBL7019167 | 0.86 | AVPR2 (0.42) | AVPR1AAVPR1BAVPR2LMNATP53 | |
| SCHEMBL7016285 | 0.86 | AVPR1A (0.44) | AVPR1AAVPR1BAVPR2LMNAPDCD1 | |
| Hydrochloric Acid SCHEMBL7018912 | 0.85 | AVPR1A (0.44) | AVPR1AAVPR1BAVPR2LMNAPDCD1 | |
| Hydrochloric Acid SCHEMBL7024085 | 0.85 | AVPR2 (0.42) | AVPR1AAVPR1BAVPR2LMNATP53 | |
| SCHEMBL7022859 | 0.83 | BRD4 (0.47) | AVPR1AAVPR1BAVPR2MEN1KMT2A | |
| SCHEMBL7019987 | 0.83 | PDE4A (0.53) | AVPR1AAVPR1BAVPR2MEN1KMT2A | |
| SCHEMBL7024187 | 0.82 | AVPR2 (0.44) | AVPR1AAVPR1BAVPR2MEN1KMT2A | |
| SCHEMBL7015488 | 0.82 | AVPR1A (0.50) | AVPR1AAVPR1BAVPR2MEN1KMT2A | |
| SCHEMBL7016054 | 0.82 | PDE4A (0.41) | AVPR1AAVPR1BAVPR2GFERRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051415-B1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO (JP) | 2003-09-24 | — | — | EP | disclosed |
| US-6495542-B1 | SUCH AS 2-METHOXY-N-(2-METHYL-1H-BENZIMIDAZOL-4-YL)-4-(2,3,4,5-TETRAHYDRO-5-OXO-1H-1-BENZAZEPIN-1-YL)CARBONYL-BENZAM IDE; HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-12-17 | — | — | US | disclosed |