Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 2/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.31 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6693568 | 1.00 | KMT2A (0.39) | KMT2AL3MBTL1GPR119MAPTACE | |
| SCHEMBL6697072 | 0.92 | KMT2A (0.39) | KMT2AL3MBTL1GPR119ACESYK | |
| SCHEMBL6699270 | 0.91 | KMT2A (0.39) | KMT2AL3MBTL1GPR119ACESYK | |
| SCHEMBL6695450 | 0.91 | KMT2A (0.39) | KMT2AL3MBTL1GPR119ACESYK | |
| SCHEMBL6697066 | 0.87 | KMT2A (0.41) | KMT2AL3MBTL1GPR119ACESYK | |
| SCHEMBL6693629 | 0.87 | KMT2A (0.41) | KMT2AL3MBTL1GPR119MAPTACE | |
| SCHEMBL6700665 | 0.87 | KMT2A (0.41) | KMT2AL3MBTL1GPR119ACESYK | |
| SCHEMBL6697044 | 0.86 | KMT2A (0.39) | KMT2AL3MBTL1GPR119ACESYK | |
| SCHEMBL6787465 | 0.86 | KMT2A (0.39) | KMT2AL3MBTL1GPR119ACESYK | |
| SCHEMBL6693641 | 0.86 | KMT2A (0.42) | KMT2AL3MBTL1GPR119ACESYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358154-A2 | PYRROLIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF NEURAMINIDASES | Abbott Laboratories (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2001028996-A2 | PYRROLIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF NEURAMINIDASES | ABBOTT LABORATORIES (US) | 2001-04-26 | — | — | WO | disclosed |