Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 9/20 | 0.64 |
| ▸ | ABL1 | P00519 | 7/20 | 0.64 |
| ▸ | EGFR | P00533 | 7/20 | 0.64 |
| ▸ | ABL2 | P42684 | 7/20 | 0.64 |
| ▸ | LCK | P06239 | 2/20 | 0.64 |
| ▸ | RIPK2 | O43353 | 8/20 | 0.60 |
| ▸ | BTK | Q06187 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7015214 | 0.91 | ABL1 (0.79) | SRCABL1EGFRABL2LCK | |
| SCHEMBL7016556 | 0.90 | SRC (0.61) | SRCABL1EGFRABL2LCK | |
| SCHEMBL7017495 | 0.89 | SRC (0.61) | SRCABL1EGFRABL2LCK | |
| SCHEMBL8108644 | 0.87 | SRC (0.67) | SRCABL1EGFRABL2LCK | |
| SCHEMBL7019630 | 0.86 | SRC (0.81) | SRCABL1EGFRABL2LCK | |
| SCHEMBL8098888 | 0.85 | SRC (0.65) | SRCABL1EGFRABL2LCK | |
| SCHEMBL7021099 | 0.84 | ABL1 (0.75) | SRCABL1EGFRABL2LCK | |
| SCHEMBL7015260 | 0.82 | SRC (0.60) | SRCABL1EGFRABL2LCK | |
| SCHEMBL8112551 | 0.81 | SRC (0.73) | SRCABL1EGFRABL2LCK | |
| SCHEMBL8108575 | 0.81 | SRC (0.71) | SRCABL1EGFRABL2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888353-B1 | N-7-HETEROCYCLYL PYRROLO [2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2003-07-09 | — | — | EP | claimed |
| EP-1362052-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | Amura Therapeutics Limited (GB) | 2003-11-19 | — | — | EP | disclosed |
| EP-0888353-B1 | N-7-HETEROCYCLYL PYRROLO [2,3-d]PYRIMIDINES AND THEIR USE | NOVARTIS AG (CH) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002057270-A1 | INHIBITORS OF CRUZIPAIN AND OTHER CYSTEINE PROTEASES | AMURA THERAPEUTICS LIMITED (GB) | 2002-07-25 | — | — | WO | disclosed |