Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 9/20 | 0.77 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019015 | 0.87 | LCK (1.00) | LCKFGFR1MKNK1MKNK2JAK2 | |
| SCHEMBL7017800 | 0.85 | LCK (0.70) | LCKMKNK1MKNK2IDH1JAK2 | |
| SCHEMBL7023575 | 0.85 | LCK (0.71) | LCKFGFR1MKNK1MKNK2ALDH1A1 | |
| SCHEMBL7020497 | 0.83 | LCK (0.71) | LCKFGFR1MKNK1MKNK2ALDH1A1 | |
| SCHEMBL7022403 | 0.81 | LCK (0.52) | LCKALDH1A1HTTIDH1 | |
| SCHEMBL7509435 | 0.78 | MKNK2 (0.52) | LCKFGFR1MKNK1MKNK2ALDH1A1 | |
| SCHEMBL7021078 | 0.78 | LCK (0.82) | LCKMKNK1MKNK2ALDH1A1IDH1 | |
| SCHEMBL7019381 | 0.78 | LCK (0.82) | LCKMKNK1MKNK2ALDH1A1IDH1 | |
| SCHEMBL7019588 | 0.78 | LCK (0.82) | LCKMKNK1MKNK2ALDH1A1IDH1 | |
| SCHEMBL7016656 | 0.78 | LCK (0.82) | LCKMKNK1MKNK2ALDH1A1IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-B1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2003-11-12 | — | — | EP | disclosed |
| US-6498165-B1 | PYRIMIDINE COMPOUNDS; PROPHYLAXIS AND TREATMENT OF SUCH AS IMMUNE DISEASES, HYPERPROLIFERATIVE DISORDERS, CANCER, ANGIOGENSIS, ATHEROSCELEROSIS, GRAFT REJECTION, RHEUMATOID ARTHRITIS, PSORIASIS | MERCK & CO., INC. | 2002-12-24 | — | — | US | disclosed |
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |