Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 18/20 | 0.83 |
| ▸ | PDE6C | P51160 | 2/20 | 0.55 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019007 | 0.91 | PDE5A (1.00) | PDE5APDE6CPDE11A | |
| SCHEMBL6290604 | 0.89 | PDE5A (1.00) | PDE5APDE6CPDE11A | |
| SCHEMBL7019096 | 0.86 | PDE5A (0.84) | PDE5APDE6CPDE11A | |
| SCHEMBL6406296 | 0.80 | PDE5A (1.00) | PDE5A | |
| SCHEMBL6407670 | 0.80 | PDE5A (1.00) | PDE5A | |
| SCHEMBL6409674 | 0.80 | PDE5A (1.00) | PDE5A | |
| SCHEMBL6412773 | 0.78 | PDE5A (1.00) | PDE5A | |
| SCHEMBL6412150 | 0.75 | PDE5A (0.84) | PDE5A | |
| SCHEMBL6407260 | 0.75 | PDE5A (1.00) | PDE5A | |
| SCHEMBL6290660 | 0.75 | PDE5A (1.00) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289985-B1 | BETA-CARBOLINE DERIVATIVES USEFUL AS INHIBITORS OF PHOSPHODIESTERASE | ORTHO MCNEIL PHARM INC (US) | 2003-12-10 | — | — | EP | claimed |