Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | KLK7 | P49862 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7020142 | 1.00 | SMN1; SMN2 (0.38) | SMN1; SMN2KMT2AMEN1TSHRSERPINE1 | |
| SCHEMBL436206 | 0.94 | KMT2A (0.35) | SMN1; SMN2KMT2AMEN1TSHRSERPINE1 | |
| SCHEMBL436205 | 0.94 | KMT2A (0.35) | SMN1; SMN2KMT2AMEN1TSHRSERPINE1 | |
| SCHEMBL6318732 | 0.92 | IDO1 (0.35) | SMN1; SMN2KMT2AMEN1CA12CA1 | |
| SCHEMBL6318728 | 0.92 | IDO1 (0.35) | SMN1; SMN2KMT2AMEN1CA12CA1 | |
| SCHEMBL6325477 | 0.91 | CA12 (0.36) | KMT2AMEN1TSHRSERPINE1CA12 | |
| SCHEMBL6325475 | 0.91 | CA12 (0.36) | KMT2AMEN1TSHRSERPINE1CA12 | |
| SCHEMBL6320297 | 0.90 | KMT2A (0.35) | SMN1; SMN2KMT2AMEN1TSHRSERPINE1 | |
| SCHEMBL6320287 | 0.90 | KMT2A (0.35) | SMN1; SMN2KMT2AMEN1TSHRSERPINE1 | |
| SCHEMBL4500161 | 0.90 | BACE1 (0.39) | SMN1; SMN2KMT2AMEN1TSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115704-B1 | NOVEL SUBSTITUTED INDOLINONES WITH AN INHIBITORY EFFECT ON VARIOUS KINASES AND CYCLIN/CDK COMPLEXES | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-06-18 | — | — | EP | disclosed |