Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.62 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | FLT4 | P35916 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | FRK | P42685 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.49 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.49 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.49 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.49 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3890883 | 0.82 | MAPK14 (0.77) | MAPK14IKBKBMAPK13PRKD3MAP4K4 | |
| SCHEMBL7026917 | 0.82 | MAPK14 (0.60) | MAPK14IKBKBMAPK13PRKD3MAP4K4 | |
| SCHEMBL3890057 | 0.81 | MAPK14 (0.77) | MAPK14IKBKBMAPK13PRKD3MAP4K4 | |
| SCHEMBL3886770 | 0.80 | MAPK14 (0.80) | MAPK14IKBKBMAPK13PRKD3MAP4K4 | |
| SCHEMBL3887409 | 0.79 | MAPK14 (0.80) | MAPK14IKBKBMAPK13PRKD3MAP4K4 | |
| SCHEMBL5203111 | 0.78 | MAPK14 (0.82) | MAPK14IKBKBMAPK13PRKD3MAP4K4 | |
| SCHEMBL3887304 | 0.78 | MAPK14 (0.81) | MAPK14IKBKBMAPK13PRKD3MAP4K4 | |
| SCHEMBL3890175 | 0.78 | MAPK14 (0.75) | MAPK14IKBKBMAPK13PRKD3MAP4K4 | |
| SCHEMBL3889480 | 0.76 | MAPK14 (0.56) | MAPK14IKBKBMAPK13PRKD3MAP4K4 | |
| SCHEMBL6807582 | 0.76 | MAPK14 (0.58) | MAPK14IKBKBMAPK13PRKD3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268474-A2 | SUBSTITUTED 1,3-THIAZOLE COMPOUNDS, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 2003-01-02 | — | — | EP | claimed |
| WO-2001074811-A2 | SUBSTITUTED 1,3-THIAZOLE COMPOUNDS, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-10-11 | — | — | WO | claimed |