Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7022486 | 0.83 | MEN1 (0.41) | MEN1KMT2ARAB9AAVPR2AVPR1A | |
| SCHEMBL7019122 | 0.83 | MAPT (0.39) | MEN1KMT2ARAB9AAVPR2AVPR1A | |
| Hydrochloric Acid SCHEMBL7017945 | 0.83 | MEN1 (0.40) | MEN1KMT2ARAB9AAVPR2AVPR1A | |
| SCHEMBL7021331 | 0.82 | AVPR2 (0.41) | MEN1KMT2AAVPR2AVPR1ANR1H2 | |
| SCHEMBL7015520 | 0.82 | PRMT5 (0.39) | AVPR2AVPR1AMAPTLMNANR1H2 | |
| SCHEMBL7014299 | 0.81 | PDE4A (0.48) | AVPR2AVPR1ALMNA | |
| SCHEMBL7019750 | 0.81 | MAPT (0.38) | MEN1KMT2ARAB9AAVPR2AVPR1A | |
| SCHEMBL7023856 | 0.80 | AVPR1A (0.38) | RAB9AAVPR2AVPR1AMAPTLMNA | |
| SCHEMBL7025753 | 0.80 | AVPR2 (0.39) | MEN1KMT2AAVPR2AVPR1ANR1H2 | |
| SCHEMBL7020351 | 0.79 | NR1H2 (0.38) | MEN1KMT2ARAB9AAVPR2AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051415-B1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO (JP) | 2003-09-24 | — | — | EP | disclosed |
| US-6495542-B1 | SUCH AS 2-METHOXY-N-(2-METHYL-1H-BENZIMIDAZOL-4-YL)-4-(2,3,4,5-TETRAHYDRO-5-OXO-1H-1-BENZAZEPIN-1-YL)CARBONYL-BENZAM IDE; HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-12-17 | — | — | US | disclosed |
| EP-1051415-A1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999037637-A1 | BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-07-29 | — | — | WO | disclosed |