Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 11/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 2/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 6/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 6/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 6/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7021574 | 0.90 | LCK (0.55) | LCKJAK2JAK3IDH1MAPK13 | |
| SCHEMBL7019097 | 0.90 | LCK (0.71) | LCKJAK2JAK3 | |
| SCHEMBL7576852 | 0.90 | LCK (0.71) | LCKJAK2JAK3 | |
| SCHEMBL7588541 | 0.85 | LCK (0.77) | LCKJAK2JAK3IDH1MAPK13 | |
| SCHEMBL7018966 | 0.85 | LCK (0.77) | LCKJAK2JAK3IDH1MAPK13 | |
| SCHEMBL7013270 | 0.83 | LCK (0.54) | LCKJAK2JAK3 | |
| SCHEMBL7504892 | 0.83 | MKNK2 (0.46) | LCK | |
| SCHEMBL7020793 | 0.79 | LCK (0.67) | LCKJAK2JAK3 | |
| SCHEMBL7571380 | 0.79 | LCK (0.67) | LCKJAK2JAK3 | |
| SCHEMBL7569631 | 0.78 | LCK (0.55) | LCKJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-B1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2003-11-12 | — | — | EP | claimed |
| US-6498165-B1 | PYRIMIDINE COMPOUNDS; PROPHYLAXIS AND TREATMENT OF SUCH AS IMMUNE DISEASES, HYPERPROLIFERATIVE DISORDERS, CANCER, ANGIOGENSIS, ATHEROSCELEROSIS, GRAFT REJECTION, RHEUMATOID ARTHRITIS, PSORIASIS | MERCK & CO., INC. | 2002-12-24 | — | — | US | claimed |
| EP-1206265-B1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2003-11-12 | — | — | EP | disclosed |
| US-6498165-B1 | PYRIMIDINE COMPOUNDS; PROPHYLAXIS AND TREATMENT OF SUCH AS IMMUNE DISEASES, HYPERPROLIFERATIVE DISORDERS, CANCER, ANGIOGENSIS, ATHEROSCELEROSIS, GRAFT REJECTION, RHEUMATOID ARTHRITIS, PSORIASIS | MERCK & CO., INC. | 2002-12-24 | — | — | US | disclosed |