Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.63 |
| ▸ | CDK1 | P06493 | 3/20 | 0.49 |
| ▸ | GSK3A | P49840 | 3/20 | 0.49 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.49 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 7/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPBWR1 | P48145 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4970615 | 0.88 | GSK3B (0.67) | GSK3BCDK1GSK3ACCNB2CCNB1 | |
| SCHEMBL7852495 | 0.87 | GSK3B (0.68) | GSK3BCDK1GSK3ACCNB2CCNB1 | |
| SCHEMBL7102813 | 0.84 | GSK3B (0.58) | GSK3BCDK1GSK3ACCNB2CCNB1 | |
| SCHEMBL4972798 | 0.81 | GSK3B (0.63) | GSK3BCDK1GSK3ACCNB2CCNB1 | |
| SCHEMBL5559061 | 0.80 | GSK3B (0.57) | GSK3BCDK1GSK3ACCNB2CCNB1 | |
| SCHEMBL7022506 | 0.79 | GSK3B (0.55) | GSK3BCDK1GSK3ACCNB2CCNB1 | |
| SCHEMBL5092254 | 0.79 | GSK3B (0.75) | GSK3BCDK1GSK3ACCNB2CCNB1 | |
| SCHEMBL5557910 | 0.78 | GSK3B (0.52) | GSK3BCDK1GSK3ACCNB2CCNB1 | |
| SCHEMBL4391839 | 0.78 | GSK3B (1.00) | GSK3BCDK1GSK3ACCNB2CCNB1 | |
| SCHEMBL29381876 | 0.78 | GSK3B (1.00) | GSK3BCDK1GSK3ACCNB2CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |
| EP-1087963-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | Chiron Corporation (US) | 2001-04-04 | — | — | EP | disclosed |
| WO-1999065897-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 1999-12-23 | — | — | WO | disclosed |