Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 18/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.44 |
| ▸ | MASP2 | O00187 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7022027 | 0.94 | F2 (0.48) | F2PRSS1MASP2PRSS2PRSS3 | |
| SCHEMBL7992846 | 0.88 | F2 (0.60) | F2PRSS1MASP2PRSS2PRSS3 | |
| SCHEMBL7026174 | 0.88 | F2 (0.60) | F2PRSS1MASP2PRSS2PRSS3 | |
| SCHEMBL7022453 | 0.87 | F2 (0.50) | F2PRSS1MASP2PRSS2PRSS3 | |
| SCHEMBL7022822 | 0.85 | F2 (0.47) | F2PRSS1MASP2PRSS2PRSS3 | |
| SCHEMBL7020324 | 0.85 | F2 (0.47) | F2PRSS1MASP2PRSS2PRSS3 | |
| SCHEMBL7023456 | 0.85 | F2 (0.47) | F2PRSS1MASP2PRSS2PRSS3 | |
| SCHEMBL7019546 | 0.85 | F2 (0.47) | F2PRSS1MASP2PRSS2PRSS3 | |
| Hydrochloric Acid SCHEMBL7027209 | 0.85 | F2 (0.47) | F2PRSS1MASP2PRSS2PRSS3 | |
| SCHEMBL7019983 | 0.85 | F2 (0.47) | F2PRSS1MASP2PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0997474-B1 | Antithrombotic agents | PFIZER (US) | 2003-10-29 | — | — | EP | claimed |
| US-6180627-B1 | INDOLE, INDAZOLE, BENZOTRIAZOLE AND BENZIMIDAZOLE DERIVATIVES | PFIZER INC. | 2001-01-30 | — | — | US | claimed |
| EP-0997474-A1 | Antithrombotic agents | PFIZER INC. (US) | 2000-05-03 | — | — | EP | claimed |
| EP-0997474-B1 | Antithrombotic agents | PFIZER (US) | 2003-10-29 | — | — | EP | disclosed |
| US-6180627-B1 | INDOLE, INDAZOLE, BENZOTRIAZOLE AND BENZIMIDAZOLE DERIVATIVES | PFIZER INC. | 2001-01-30 | — | — | US | disclosed |
| EP-0997474-A1 | Antithrombotic agents | PFIZER INC. (US) | 2000-05-03 | — | — | EP | disclosed |