Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.37 |
| ▸ | TCF7L2 | Q9NQB0 | 2/20 | 0.37 |
| ▸ | CIT | O14578 | 1/20 | 0.37 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.37 |
| ▸ | STK10 | O94804 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | YES1 | P07947 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | HCK | P08631 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6105874 | 0.94 | KDR (0.42) | KDRPDPK1CTNNB1TCF7L2CIT | |
| SCHEMBL6104364 | 0.94 | KDR (0.42) | KDRPDPK1CTNNB1TCF7L2CIT | |
| SCHEMBL6104030 | 0.89 | KDR (0.46) | KDRPDPK1CITMAP3K7RIPK2 | |
| SCHEMBL6106380 | 0.89 | KDR (0.46) | KDRPDPK1CITMAP3K7RIPK2 | |
| SCHEMBL444629 | 0.89 | KDR (0.49) | KDRCITMAP3K7RIPK2STK10 | |
| SCHEMBL446808 | 0.89 | KDR (0.49) | KDRCITMAP3K7RIPK2STK10 | |
| SCHEMBL7159530 | 0.89 | KDR (0.49) | KDRCITMAP3K7RIPK2STK10 | |
| SCHEMBL6104937 | 0.89 | PDPK1 (0.44) | KDRPDPK1CTNNB1TCF7L2CIT | |
| SCHEMBL6106169 | 0.84 | PDPK1 (0.47) | KDRPDPK1CITMAP3K7RIPK2 | |
| SCHEMBL6106136 | 0.84 | PDPK1 (0.47) | KDRPDPK1CITMAP3K7RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358161-A2 | N-PYRIDYL CARBOXAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Amgen Inc. (US) | 2003-11-05 | — | — | EP | disclosed |
| WO-2002055501-A2 | N-PYRIDYL CARBOXAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AMGEN INC (US) | 2002-07-18 | — | — | WO | disclosed |