Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 2/20 | 0.30 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.30 |
| ▸ | SUV39H1 | O43463 | 1/20 | 0.30 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7015453 | 0.82 | TDP1 (0.45) | MEN1KMT2A | |
| SCHEMBL1626152 | 0.81 | RAD52 (0.42) | PDE4BRETRAD52MEN1KMT2A | |
| SCHEMBL1629448 | 0.81 | RAD52 (0.42) | PDE4BRETRAD52MEN1KMT2A | |
| SCHEMBL6386479 | 0.80 | GAA (0.40) | MEN1KMT2A | |
| SCHEMBL7020726 | 0.80 | GAA (0.40) | MEN1KMT2A | |
| SCHEMBL6387368 | 0.80 | GAA (0.40) | MEN1KMT2A | |
| SCHEMBL27597644 | 0.79 | BRAF (0.36) | PDE4BRETRAD52MEN1KMT2A | |
| SCHEMBL6441185 | 0.72 | MAPT (0.48) | MEN1KMT2A | |
| SCHEMBL7020352 | 0.68 | MAPT (0.40) | MEN1KMT2A | |
| SCHEMBL1625505 | 0.68 | MEN1 (0.49) | RAD52MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326606-A2 | EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS | PFIZER PHARMACEUTICALS INC. (JP) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002032422-A2 | EP4 RECEPTOR INHIBITORS TO TREAT RHEUMATOID ARTHRITIS | PFIZER PHARMACEUTICALS INC. (JP) | 2002-04-25 | — | — | WO | disclosed |