Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | HBB | P68871 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13660595 | 1.00 | HRH3 (0.67) | HRH3SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL4296193 | 1.00 | HRH3 (0.67) | HRH3SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL4296185 | 1.00 | HRH3 (0.67) | HRH3SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL6699692 | 0.81 | HRH3 (1.00) | HRH3MAPTKDM4EMEN1KMT2A | |
| SCHEMBL4430247 | 0.81 | HRH3 (0.67) | HRH3SMN1; SMN2RAB9AKDM4EMEN1 | |
| SCHEMBL4297640 | 0.81 | HRH3 (0.67) | HRH3KDM4EMEN1KMT2AKDR | |
| SCHEMBL4430239 | 0.81 | HRH3 (0.67) | HRH3SMN1; SMN2RAB9AKDM4EMEN1 | |
| SCHEMBL4424834 | 0.81 | HRH3 (1.00) | HRH3MAPTKDM4EMEN1KMT2A | |
| SCHEMBL4297644 | 0.81 | HRH3 (0.67) | HRH3KDM4EMEN1KMT2AKDR | |
| SCHEMBL6701750 | 0.81 | HRH3 (1.00) | HRH3MAPTKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326863-A2 | OCTAHYDRO-INDOLIZINES AND QUINOLIZINES AND HEXAHYDRO-PYRROLIZINES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-07-16 | — | — | EP | claimed |
| WO-2002024695-A2 | OCTAHYDRO-INDOLIZINES AND QUINOLIZINES AND HEXAHYDRO-PYRROLIZINES | ORTHO MCNEIL PHARMACEUTICAL, INC. (US) | 2002-03-28 | — | — | WO | claimed |