Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.48 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.35 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4292577 | 1.00 | HRH3 (0.48) | HRH3SCD5MMP2MMP9CYP2D6 | |
| SCHEMBL4302483 | 1.00 | HRH3 (0.48) | HRH3SCD5MMP2MMP9CYP2D6 | |
| SCHEMBL4302481 | 1.00 | HRH3 (0.48) | HRH3SCD5MMP2MMP9CYP2D6 | |
| SCHEMBL30423589 | 0.82 | HCRTR1 (0.40) | HRH3SCD5MMP2MMP9CYP2D6 | |
| SCHEMBL4292359 | 0.80 | HRH3 (0.55) | HRH3MAOBMEN1KMT2A | |
| SCHEMBL13660570 | 0.80 | HRH3 (0.55) | HRH3MAOBMEN1KMT2A | |
| SCHEMBL4292349 | 0.79 | HRH3 (0.56) | HRH3CYP2D6 | |
| SCHEMBL13660535 | 0.79 | HRH3 (0.56) | HRH3CYP2D6 | |
| SCHEMBL4295391 | 0.77 | HRH3 (0.55) | HRH3 | |
| SCHEMBL4295389 | 0.77 | HRH3 (0.55) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326863-A2 | OCTAHYDRO-INDOLIZINES AND QUINOLIZINES AND HEXAHYDRO-PYRROLIZINES | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002024695-A2 | OCTAHYDRO-INDOLIZINES AND QUINOLIZINES AND HEXAHYDRO-PYRROLIZINES | ORTHO MCNEIL PHARMACEUTICAL, INC. (US) | 2002-03-28 | — | — | WO | disclosed |