Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.42 |
| ▸ | APP | P05067 | 3/20 | 0.38 |
| ▸ | SNCA | P37840 | 3/20 | 0.38 |
| ▸ | CNR1 | P21554 | 4/20 | 0.36 |
| ▸ | CNR2 | P34972 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6223092 | 0.82 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DPTGDR2 | |
| SCHEMBL6221716 | 0.75 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DPTGDR2 | |
| SCHEMBL6221877 | 0.74 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DPTGDR2 | |
| SCHEMBL6224864 | 0.74 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DAPP | |
| SCHEMBL7021842 | 0.73 | TP53 (0.47) | PDE4APDE4BPDE4CPDE4DAPP | |
| SCHEMBL5557262 | 0.72 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DCNR1 | |
| SCHEMBL6222086 | 0.72 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DPTGDR2 | |
| SCHEMBL6224573 | 0.72 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DPTGDR2 | |
| SCHEMBL6220300 | 0.71 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DPTGDR2 | |
| SCHEMBL6223861 | 0.71 | PDE4A (0.84) | PDE4APDE4BPDE4CPDE4DPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1330455-A1 | NOVEL 7-AZAINDOLES, USE THEREOF AS PHOSPHODIESTERASE 4 INHIBITORS AND METHOD FOR PRODUCING THE SAME | Elbion AG (DE) | 2003-07-30 | — | — | EP | claimed |
| WO-2002034747-A1 | NOVEL 7-AZAINDOLES, USE THEREOF AS PHOSPHODIESTERASE 4 INHIBITORS AND METHOD FOR PRODUCING THE SAME | ELBION AG (DE) | 2002-05-02 | — | — | WO | claimed |