Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT3 | Q9NTG7 | 7/20 | 0.75 |
| ▸ | KDM5A | P29375 | 7/20 | 0.75 |
| ▸ | THRA | P10827 | 3/20 | 0.75 |
| ▸ | THRB | P10828 | 3/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.75 |
| ▸ | TP53 | P04637 | 2/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.75 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.75 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.75 |
| ▸ | KDM7A | Q6ZMT4 | 2/20 | 0.75 |
| ▸ | MLNR | O43193 | 1/20 | 0.75 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.75 |
| ▸ | PHF2 | O75151 | 1/20 | 0.75 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.75 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.75 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.75 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.75 |
| ▸ | FYN | P06241 | 1/20 | 0.75 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4710390 | 0.91 | KDM5A (0.78) | SIRT3KDM5ATHRATHRBALDH1A1 | |
| SCHEMBL16058797 | 0.89 | SIRT3 (0.79) | SIRT3KDM5ATHRATHRBALDH1A1 | |
| Budiodarone SCHEMBL1946426 | 0.89 | SIRT3 (0.70) | SIRT3KDM5ATHRATHRBALDH1A1 | |
| SCHEMBL14192201 | 0.89 | SIRT3 (0.70) | SIRT3KDM5ATHRATHRBALDH1A1 | |
| Budiodarone SCHEMBL29380098 | 0.89 | SIRT3 (0.70) | SIRT3KDM5ATHRATHRBALDH1A1 | |
| SCHEMBL14192200 | 0.89 | SIRT3 (0.70) | SIRT3KDM5ATHRATHRBALDH1A1 | |
| Budiodarone SCHEMBL1946428 | 0.89 | SIRT3 (0.70) | SIRT3KDM5ATHRATHRBALDH1A1 | |
| Budiodarone SCHEMBL3123242 | 0.89 | SIRT3 (0.70) | SIRT3KDM5ATHRATHRBALDH1A1 | |
| Amiodarone SCHEMBL12487240 | 0.86 | SIRT3 (1.00) | SIRT3KDM5ATHRATHRBALDH1A1 | |
| SCHEMBL13654918 | 0.86 | SIRT3 (0.77) | SIRT3KDM5ATHRATHRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002038557-A9 | BENZOYLBENZOFURANE DERIVATIVES FOR TREATMENT OF CARDIAC ARRHYTHMIA | ARYX THERAPEUTICS (US) | 2003-09-18 | — | — | WO | disclosed |
| EP-1322630-A2 | BENZOYLBENZOFURANE DERIVATIVES FOR TREATMENT OF CARDIAC ARRHYTHMIA | Aryx Therapeutics (US) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002038557-A2 | BENZOYLBENZOFURANE DERIVATIVES FOR TREATMENT OF CARDIAC ARRHYTHMIA | ARYX THERAPEUTICS (US) | 2002-05-16 | — | — | WO | disclosed |
| US-6316487-B1 | FOR THERAPY OF VENTRICULAR TACHYARRHYTHMIAS, ESPECIALLY IN PATIENTS WITH CONGESTIVE HEART FAILURE AND VENTRICULAR ARRHYTHMIAS AND SUPRAVENTRICULAR ARRHYTHMIAS, INCLUDING ATRIAL FIBRILLATION AND RE-ENTRANT TACHYARRHYTHMIAS | ARYX THERAPEUTICS | 2001-11-13 | — | — | US | disclosed |
| US-6130240-A | Compound for treatment of cardiac arrhythmia, synthesis, and methods of use | ARYX THERAPEUTICS, INC. (US) | 2000-10-10 | — | — | US | disclosed |
| EP-0703910-B1 | BENZOYLBENZOFURANE DERIVATIVES FOR TREATMENT OF CARDIAC ARRHYTHMIA | ARYX THERAPEUTICS (US) | 1998-01-07 | — | — | EP | disclosed |
| US-5440054-A | Compound for treatment of cardiac arrhythmia, synthesis, and methods of use | ADVANCED THERAPIES, INC. (US) | 1995-08-08 | — | — | US | disclosed |
| US-5364880-A | Compound for treatment of cardiac arrhythmia, synthesis, and methods of use | ADVANCED THERAPIES, INC. (US) | 1994-11-15 | — | — | US | disclosed |