Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.85 |
| ▸ | POLB | P06746 | 6/20 | 0.85 |
| ▸ | GAA | P10253 | 2/20 | 0.85 |
| ▸ | PKM | P14618 | 2/20 | 0.85 |
| ▸ | MAPT | P10636 | 2/20 | 0.85 |
| ▸ | PPARG | P37231 | 1/20 | 0.85 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.85 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.85 |
| ▸ | G6PD | P11413 | 1/20 | 0.65 |
| ▸ | GFER | P55789 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.55 |
| ▸ | CTSB | P07858 | 1/20 | 0.55 |
| ▸ | ELANE | P08246 | 1/20 | 0.55 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL703013 | 1.00 | MEN1 (0.85) | MEN1KMT2APOLBGAAPKM | |
| SCHEMBL10091732 | 1.00 | MEN1 (0.85) | MEN1KMT2APOLBGAAPKM | |
| SCHEMBL10091725 | 0.84 | MEN1 (0.61) | MEN1KMT2APOLBGAAPKM | |
| SCHEMBL10091727 | 0.83 | MEN1 (0.60) | MEN1KMT2APOLBGAAPKM | |
| SCHEMBL10091726 | 0.78 | PIM1 (0.56) | MEN1KMT2APOLBGAAPKM | |
| SCHEMBL5145439 | 0.78 | MEN1 (1.00) | MEN1KMT2APOLBGAAPKM | |
| SCHEMBL706219 | 0.77 | PIM1 (0.71) | MEN1KMT2APOLBGAAPKM | |
| SCHEMBL10091754 | 0.77 | PIM1 (0.71) | MEN1KMT2APOLBGAAPKM | |
| SCHEMBL706220 | 0.77 | PIM1 (0.71) | MEN1KMT2APOLBGAAPKM | |
| SCHEMBL10091758 | 0.76 | MEN1 (0.52) | MEN1KMT2APOLBGAAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120190669-A1 | OXINDOLE COMPOUNDS | CYLENE PHARMACEUTICALS, INC. (US) | 2012-07-26 | — | — | US | disclosed |
| US-8124649-B2 | Oxindole compounds | CYLENE PHARMACEUTICALS, INC. (US) | 2012-02-28 | — | — | US | disclosed |
| EP-2307421-A1 | OXINDOLE COMPOUNDS | Cylene Pharmaceuticals, Inc. (US) | 2011-04-13 | — | — | EP | disclosed |
| US-20100041635-A1 | OXINDOLE COMPOUNDS | CYLENE PHARMACEUTICALS, INC. | 2010-02-18 | — | — | US | disclosed |
| WO-2010002933-A1 | OXINDOLE COMPOUNDS | CYLENE PHARMACEUTICALS, INC. (US) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041635-A1 | OXINDOLE COMPOUNDS | FLT3, PIM1, PIM2 | MEN1 3039/4885KMT2A 1375/4885POLB 2906/4885 |
| US-20120190669-A1 | OXINDOLE COMPOUNDS | FLT3, PIM1, PIM2 | MEN1 3039/4885KMT2A 1375/4885POLB 2906/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.