Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.49 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.49 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.49 |
| ▸ | KDM4A | O75164 | 4/20 | 0.47 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 8/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | ALPG | P10696 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL7030958 | 1.00 | CHRM2 (0.49) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Iodide SCHEMBL7028953 | 0.95 | CHRM2 (0.51) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Iodide SCHEMBL7028950 | 0.95 | CHRM2 (0.51) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Iodide SCHEMBL7034960 | 0.88 | CHRM2 (0.48) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Iodide SCHEMBL7034965 | 0.88 | CHRM2 (0.48) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| SCHEMBL7035147 | 0.87 | CHRM2 (0.42) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Iodide SCHEMBL7032402 | 0.87 | CHRM2 (0.54) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Iodide SCHEMBL7035375 | 0.87 | KDM4A (0.49) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Iodide SCHEMBL7032404 | 0.87 | CHRM2 (0.54) | CHRM2CHRM4CHRM5CHRM1CHRM3 | |
| Iodide SCHEMBL7035383 | 0.87 | KDM4A (0.49) | CHRM2CHRM4CHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030022105-A1 | TWO -PHOTON UPCONVERTING DYES AND APPLICATIONS | PRASAD PARAS N (US) | 2003-01-30 | — | — | US | disclosed |
| US-6402037-B1 | Two-photon upconverting dyes and applications | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | 2002-06-11 | — | — | US | disclosed |
| EP-0862432-A1 | TWO-PHOTON UPCONVERTING DYES AND APPLICATIONS | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 1998-09-09 | — | — | EP | disclosed |
| WO-1997009043-A1 | TWO-PHOTON UPCONVERTING DYES AND APPLICATIONS | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 1997-03-13 | — | — | WO | disclosed |