SCHEMBL703169

SCHEMBL703169

S=C1C=CC(=S)N1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10613332 0.37
SCHEMBL31203085 0.35
SCHEMBL29889134 0.30
SCHEMBL29612863 0.30
SCHEMBL29908294 0.30
SCHEMBL30149517 0.30
Methane SCHEMBL23044967 0.30
SCHEMBL6559802 0.30
SCHEMBL156040 0.30
SCHEMBL7913046 0.30

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 250 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4735958-A1 PHOTORESIST PATTERNING IN MULTI-DEPTH NANOWELLS Illumina, Inc. (US) 2026-05-06 EP claimed
WO-2026044039-A2 ANTI-CD73 ANTIBODIES, CONJUGATES, AND METHODS OF USE EISAI R&D MANAGEMENT CO., LTD. (JP) 2026-02-26 WO claimed
US-20260038886-A1 SULFONE-BASED ELECTROLYTE AND SECONDARY BATTERY COMPRISING SAME DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2026-02-05 US claimed
US-20250010291-A1 PHOTORESIST PATTERNING IN MULTI-DEPTH NANOWELLS ILLUMINA, INC. 2025-01-09 US claimed
WO-2025006431-A1 PHOTORESIST PATTERNING IN MULTI-DEPTH NANOWELLS ILLUMINA, INC. (US) 2025-01-02 WO claimed
CN-118256468-A Modified ToPif1 helicase and application thereof 北京普译生物科技有限公司 2024-06-28 CN claimed
CN-118126984-A Modified PAE CASDING helicase and application thereof 北京普译生物科技有限公司 2024-06-04 CN claimed
CN-118126983-A Modified MPK2 helicase and application thereof 北京普译生物科技有限公司 2024-06-04 CN claimed
WO-2024019272-A1 SULFONE-BASED ELECTROLYTE AND SECONDARY BATTERY COMPRISING SAME 재단법인대구경북과학기술원 2024-01-25 WO claimed
CN-115948112-A Waterborne polyurethane coating and preparation process thereof 成都鑫岩乔新材料科技有限公司 2023-04-11 CN claimed
CN-111378173-A Force-responsive crosslinked polymer 翁秋梅 2020-07-07 CN claimed
CN-111378180-A Force-responsive crosslinked polymer 翁秋梅 2020-07-07 CN claimed
CN-111378170-A Force-responsive crosslinked polymer 翁秋梅 2020-07-07 CN claimed
CN-100360554-C peptide conjugates UNIV KEIO (JP) 2008-01-09 CN claimed
US-20070059376-A1 Peptide conjugate KEIO UNIVERSITY (JP) 2007-03-15 US claimed
EP-1646625-A1 PYRROLE-2, 5-DITHIONE DERIVATIVES AS LIVER X RECEPTOR MODULATORS AstraZeneca AB (SE) 2006-04-19 EP claimed
CN-1747967-A Peptide conjugate UNIV KEIO (JP) 2006-03-15 CN claimed
EP-1591451-A1 PEPTIDE CONJUGATE Keio University (JP) 2005-11-02 EP claimed
WO-2005005416-A1 PYRROLE-2, 5-DITHIONE DERIVATIVES AS LIVER X RECEPTOR MODULATORS ASTRAZENECA AB (SE) 2005-01-20 WO claimed
US-20260139068-A1 ANTI-CD73 ANTIBODIES, CONJUGATES, AND METHODS OF USE EISAI R&D MAN CO LTD (JP) 2026-05-21 US disclosed
EP-4735958-A1 PHOTORESIST PATTERNING IN MULTI-DEPTH NANOWELLS Illumina, Inc. (US) 2026-05-06 EP disclosed
WO-2026044039-A2 ANTI-CD73 ANTIBODIES, CONJUGATES, AND METHODS OF USE EISAI R&D MANAGEMENT CO., LTD. (JP) 2026-02-26 WO disclosed
US-20260038886-A1 SULFONE-BASED ELECTROLYTE AND SECONDARY BATTERY COMPRISING SAME DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2026-02-05 US disclosed
US-20260028420-A1 ANTI-TUMOR ANTIBODIES IMMUNOME INC (US) 2026-01-29 US disclosed
US-20260022193-A1 METHODS OF TREATMENT USING A BISPECIFIC ANTIGEN-BINDING CONSTRUCT TARGETING HER2 ZYMEWORKS BC INC (CA) 2026-01-22 US disclosed
US-20250339552-A1 ANTIBODY-DRUG CONJUGATES TARGETING FOLATE RECEPTOR ALPHA AND METHODS OF USE ZYMEWORKS BC INC (CA) 2025-11-06 US disclosed
US-12435157-B2 Methods of using a bispecific antigen-binding construct targeting HER2 for the treatment of biliary tract cancers ZYMEWORKS BC INC. (CA) 2025-10-07 US disclosed
US-12433952-B2 Antibody-drug conjugates targeting folate receptor alpha and methods of use ZYMEWORKS BC INC. (CA) 2025-10-07 US disclosed
US-20250295799-A1 ANTIBODY-DRUG CONJUGATES TARGETING GLYPICAN-3 AND METHODS OF USE ZYMEWORKS BC INC. (CA) 2025-09-25 US disclosed
US-20250276077-A1 EPHA2 ANTIBODIES IMMUNOME INC (US) 2025-09-04 US disclosed
US-20250277030-A1 ANTI-NAPI2B ANTIBODIES AND METHODS OF USE ZYMEWORKS BC INC. (CA) 2025-09-04 US disclosed
EP-4605426-A1 ANTIBODY-DRUG CONJUGATES TARGETING NAPI2B AND METHODS OF USE Zymeworks BC Inc. (CA) 2025-08-27 EP disclosed
EP-4605427-A1 ANTI-NAPI2B ANTIBODIES AND METHODS OF USE Zymeworks BC Inc. (CA) 2025-08-27 EP disclosed
EP-4594354-A1 ANTIBODY DRUG CONJUGATES TARGETING C-MET AND METHODS OF USE Zymeworks BC Inc. (CA) 2025-08-06 EP disclosed
US-20250235548-A1 ANTIBODY-DRUG CONJUGATES TARGETING NAPI2B AND METHODS OF USE ZYMEWORKS BC INC. (CA) 2025-07-24 US disclosed
US-12357701-B2 Anti-HER2 biparatopic antibody-drug conjugates and methods of use ZYMEWORKS BC INC. (CA) 2025-07-15 US disclosed
US-20250222128-A1 ANTIBODY DRUG-CONJUGATES TARGETING C-MET AND METHODS OF USE THEREOF ZYMEWORKS BC INC. (CA) 2025-07-10 US disclosed
EP-4562011-A1 IMMUNOMODULATOR PURINE-DERIVED COMPOUNDS, CONJUGATES THEREOF, AND METHODS OF USE THEREOF Zymeworks BC Inc. (CA) 2025-06-04 EP disclosed
US-20250170266-A1 IMMUNOMODULATOR PURINE-DERIVED COMPOUNDS, CONJUGATES THEREOF, AND METHODS OF USE THEREOF ZYMEWORKS BC INC. (CA) 2025-05-29 US disclosed
CN-120051492-A Anti-NAPI 2B antibodies and methods of use 酵活英属哥伦比亚有限公司 2025-05-27 CN disclosed
CN-120019075-A Antibody drug conjugates targeting C-MET and methods of use 酵活英属哥伦比亚有限公司 2025-05-16 CN disclosed
WO-2025093562-A1 ANTIBODY-DRUG CONJUGATES HAVING A TAILOR-MADE DRUG-TO-ANTIBODY RATIO BioNTech SE (DE) 2025-05-08 WO disclosed
EP-4548936-A1 ANTIBODY-DRUG CONJUGATES HAVING A TAILOR-MADE DRUG-TO-ANTIBODY RATIO BioNTech SE (DE) 2025-05-07 EP disclosed
CN-119948062-A NAPI 2B-targeted antibody-drug conjugates and methods of use thereof 酵活英属哥伦比亚有限公司 2025-05-06 CN disclosed
CN-114025795-B Methods of treating biliary tract cancer using bispecific antigen binding constructs that target HER2 酵活英属哥伦比亚有限公司 2025-04-29 CN disclosed
US-12286488-B2 Anti-dinitolmide monoclonal antibodies and hybridoma cell strain that secretes them JIANGNAN UNIVERSITY (CN) 2025-04-29 US disclosed
WO-2025081282-A1 ANTI-NAPI2B ANTIBODY-DRUG CONJUGATES AND METHODS OF USE ZYMEWORKS BC INC. (CA) 2025-04-24 WO disclosed
EP-4504798-A1 ANTI-TUMOR ANTIBODIES Immunome, Inc. (US) 2025-02-12 EP disclosed
EP-4499698-A1 ANTIBODY-DRUG CONJUGATES TARGETING FOLATE RECEPTOR ALPHA AND METHODS OF USE Zymeworks BC Inc. (CA) 2025-02-05 EP disclosed
EP-4499697-A1 ANTI-FOLATE RECEPTOR ALPHA ANTIBODIES AND METHODS OF USE Zymeworks BC Inc. (CA) 2025-02-05 EP disclosed
US-20250010291-A1 PHOTORESIST PATTERNING IN MULTI-DEPTH NANOWELLS ILLUMINA, INC. 2025-01-09 US disclosed
US-20250009788-A1 METHODS OF USING A BISPECIFIC ANTIGEN-BINDING CONSTRUCT TARGETING HER2 IN COMBINATION WITH CDK4/6 INHIBITORS FOR THE TREATMENT OF BREAST CANCER ZYMEWORKS INC. (CA) 2025-01-09 US disclosed
WO-2025006431-A1 PHOTORESIST PATTERNING IN MULTI-DEPTH NANOWELLS ILLUMINA, INC. (US) 2025-01-02 WO disclosed
US-20240424125-A1 ANTIBODY-DRUG CONJUGATES TARGETING FOLATE RECEPTOR ALPHA AND METHODS OF USE ZYMEWORKS BC INC. (CA) 2024-12-26 US disclosed
US-20240376154-A1 BIS-INTERCALATING PEPTIDES, CONJUGATES AND METHODS OF USE ZYMEWORKS BC INC. (CA) 2024-11-14 US disclosed
CN-118922447-A Folate receptor alpha-targeting antibody-drug conjugates and methods of use 酵活英属哥伦比亚有限公司 2024-11-08 CN disclosed
WO-2023178451-A9 ANTI-FOLATE RECEPTOR ALPHA ANTIBODIES AND METHODS OF USE ZYMEWORKS BC INC. (CA) 2024-11-07 WO disclosed
EP-4312851-B1 MECHANOCHROMIC PRESSURE SENSOR FOR SAFE AND EFFECTIVE TISSUE HANDLING IN MINIMALLY INVASIVE SURGERY FONDAZIONE ST ITALIANO TECNOLOGIA (IT) 2024-10-09 EP disclosed
US-12076400-B2 Methods of using a bispecific antigen-binding construct targeting HER2 in combination with CDK4/6 inhibitors for the treatment of breast cancer ZYMEWORKS BC INC. (CA) 2024-09-03 US disclosed
US-20240269309-A1 CAMPTOTHECIN ANALOGUES, CONJUGATES AND METHODS OF USE ZYMEWORKS INC. (CA) 2024-08-15 US disclosed
US-12050403-B2 Organic-inorganic hybrid photoresist processing liquid composition YOUNG CHANG CHEMICAL CO., LTD (KR) 2024-07-30 US disclosed
CN-118256468-A Modified ToPif1 helicase and application thereof 北京普译生物科技有限公司 2024-06-28 CN disclosed
US-20240180576-A1 MECHANOCHROMIC PRESSURE SENSOR FOR SAFE AND EFFECTIVE TISSUE HANDLING IN MINIMALLY INVASIVE SURGERY FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) 2024-06-06 US disclosed
CN-118126984-A Modified PAE CASDING helicase and application thereof 北京普译生物科技有限公司 2024-06-04 CN disclosed
CN-118126983-A Modified MPK2 helicase and application thereof 北京普译生物科技有限公司 2024-06-04 CN disclosed
WO-2024082056-A1 ANTI-NAPI2B ANTIBODIES AND METHODS OF USE ZYMEWORKS BC INC. (CA) 2024-04-25 WO disclosed
WO-2024082051-A1 ANTIBODY-DRUG CONJUGATES TARGETING GLYPICAN-3 AND METHODS OF USE ZYMEWORKS BC INC. (CA) 2024-04-25 WO disclosed
WO-2024082055-A1 ANTIBODY-DRUG CONJUGATES TARGETING NAPI2B AND METHODS OF USE ZYMEWORKS BC INC. (CA) 2024-04-25 WO disclosed
EP-4347601-A1 CAMPTOTHECIN ANALOGUES, CONJUGATES AND METHODS OF USE Zymeworks BC Inc. (CA) 2024-04-10 EP disclosed
WO-2024065056-A1 ANTIBODY DRUG CONJUGATES TARGETING C-MET AND METHODS OF USE ZYMEWORKS BC INC. (CA) 2024-04-04 WO disclosed
CN-117715914-A Camptothecin analogs, conjugates, and methods of use 酵活英属哥伦比亚有限公司 2024-03-15 CN disclosed
EP-4312851-A1 MECHANOCHROMIC PRESSURE SENSOR FOR SAFE AND EFFECTIVE TISSUE HANDLING IN MINIMALLY INVASIVE SURGERY Fondazione Istituto Italiano di Tecnologia (IT) 2024-02-07 EP disclosed
WO-2024020684-A1 IMMUNOMODULATOR PURINE-DERIVED COMPOUNDS, CONJUGATES THEREOF, AND METHODS OF USE THEREOF ZYMEWORKS BC INC. (CA) 2024-02-01 WO disclosed
WO-2024019272-A1 SULFONE-BASED ELECTROLYTE AND SECONDARY BATTERY COMPRISING SAME 재단법인대구경북과학기술원 2024-01-25 WO disclosed
WO-2024006973-A1 ENGINEERED HUMAN SERINE DEHYDRATASE ENZYMES AND METHODS FOR TREATING CANCER BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2024-01-04 WO disclosed
WO-2023196824-A1 ANTI-TUMOR ANTIBODIES ATRECA, INC. (US) 2023-10-12 WO disclosed
WO-2023196869-A1 EPHA2 ANTIBODIES ATRECA, INC. (US) 2023-10-12 WO disclosed
EP-4253421-A2 ANTI-HER2 BIPARATOPIC ANTIBODY-DRUG CONJUGATES AND METHODS OF USE Zymeworks BC Inc. (CA) 2023-10-04 EP disclosed
WO-2023178451-A1 ANTI-FOLATE RECEPTOR ALPHA ANTIBODIES AND METHODS OF USE ZYMEWORKS BC INC. (CA) 2023-09-28 WO disclosed
WO-2023178452-A1 ANTIBODY-DRUG CONJUGATES TARGETING FOLATE RECEPTOR ALPHA AND METHODS OF USE ZYMEWORKS BC INC. (CA) 2023-09-28 WO disclosed
CN-116199728-B Galactose diselenide fluorescent probe and preparation method and application thereof 南京工业大学 2023-09-19 CN disclosed
CN-116603073-A Platelet-loaded small molecule pharmaceutical preparation, and preparation method and application thereof 上海臻上医药科技有限公司 2023-08-18 CN disclosed
WO-2023141714-A1 METHODS OF USING ANTI-HER2 BIPARATOPIC ANTIBODY-DRUG CONJUGATES IN THE TREATMENT OF CANCER ZYMEWORKS BC INC. (CA) 2023-08-03 WO disclosed
EP-3765525-B1 ANTI-HER2 BIPARATOPIC ANTIBODY-DRUG CONJUGATES AND METHODS OF USE ZYMEWORKS BC INC (CA) 2023-07-19 EP disclosed
CN-116199728-A Galactose diselenide fluorescent probe and preparation method and application thereof 南京工业大学 2023-06-02 CN disclosed
CN-116173237-A Pharmaceutical formulation, method for the production thereof, and use thereof 上海臻上医药科技有限公司 2023-05-30 CN disclosed
CN-115948112-A Waterborne polyurethane coating and preparation process thereof 成都鑫岩乔新材料科技有限公司 2023-04-11 CN disclosed
CN-115948112-A Waterborne polyurethane coating and preparation process thereof 成都鑫岩乔新材料科技有限公司 2023-04-11 CN disclosed
CN-111378141-B Force-induced response supramolecular polymer 厦门天策材料科技有限公司 2023-04-07 CN disclosed
US-11591579-B2 Human methylthioadenosine/adenosine depleting enzyme variants for cancer therapy BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2023-02-28 US disclosed
CN-111040204-B Force-induced response dynamic polymer and application thereof 厦门天策材料科技有限公司 2023-01-24 CN disclosed
EP-4087922-A1 IMPROVED HUMAN METHYLTHIOADENOSINE/ADENOSINE DEPLETING ENZYME VARIANTS FOR CANCER THERAPY Board of Regents, The University of Texas System (US) 2022-11-16 EP disclosed
CN-115244175-A Improved human methylthioadenosine/adenosine depleting enzyme variants for cancer treatment 得克萨斯大学体系董事会 2022-10-25 CN disclosed
WO-2022201024-A1 MECHANOCHROMIC PRESSURE SENSOR FOR SAFE AND EFFECTIVE TISSUE HANDLING IN MINIMALLY INVASIVE SURGERY FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) 2022-09-29 WO disclosed
US-11430973-B2 Adhesive for lithium-ion electrode, electrode for lithium-ion battery and method for manufacturing electrode for lithium-ion battery SANYO CHEMICAL INDUSTRIES, LTD. (JP) 2022-08-30 US disclosed
US-20220257789-A1 ANTI-TISSUE FACTOR ANTIBODY-DRUG CONJUGATES AND RELATED METHODS EXELIXIS, INC. 2022-08-18 US disclosed
US-11396647-B2 Human methylthioadenosine/adenosine depleting enzyme variants for cancer therapy BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2022-07-26 US disclosed
CN-109152845-B Comprising at least two (-CH) s within a ring2-CH2Conjugates of linkers of-O-) units and conjugation reagents 宝力泰锐克斯有限公司 2022-07-12 CN disclosed
EP-3994150-A1 ANTI-TISSUE FACTOR ANTIBODY-DRUG CONJUGATES AND RELATED METHODS Iconic Therapeutics, Inc. (US) 2022-05-11 EP disclosed
US-20220133903-A1 METHODS OF USING A BISPECIFIC ANTIGEN-BINDING CONSTRUCT TARGETING HER2 FOR THE TREATMENT OF BILIARY TRACT CANCERS ZYMEWORKS BC INC. (CA) 2022-05-05 US disclosed
CN-109790178-B Novel cytotoxic agents and conjugates thereof 宝力泰锐克斯有限公司 2022-05-03 CN disclosed
CN-108465112-B Self-stabilizing linker conjugates 西雅图基因公司 2022-04-29 CN disclosed
EP-3976098-A1 METHODS OF USING A BISPECIFIC ANTIGEN-BINDING CONSTRUCT TARGETING HER2 FOR THE TREATMENT OF BILIARY TRACT CANCERS Zymeworks Inc. (CA) 2022-04-06 EP disclosed
CN-114222752-A Anti-tissue factor antibody-drug conjugates and related methods 伊科尼克治疗公司 2022-03-22 CN disclosed
CN-111040110-B Force-induced response dynamic polymer and application thereof 厦门天策材料科技有限公司 2022-03-11 CN disclosed
US-20220047683-A1 HUMAN METHYLTHIOADENOSINE/ADENOSINE DEPLETING ENZYME VARIANTS FOR CANCER THERAPY BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2022-02-17 US disclosed
CN-114025795-A Methods of treating biliary tract cancer using bispecific antigen-binding constructs targeting HER2 酵活有限公司 2022-02-08 CN disclosed
CN-113997650-A Multilayer structure assembly with force-induced responsiveness 厦门天策材料科技有限公司 2022-02-01 CN disclosed
CN-114001114-A Flexible energy absorption system with concave corner structure 厦门天策材料科技有限公司 2022-02-01 CN disclosed
CN-113980335-A 3D printing dilatancy energy-absorbing structure and preparation method thereof 厦门天策材料科技有限公司 2022-01-28 CN disclosed
US-20210346508-A1 ANTI-HER2 BIPARATOPIC ANTIBODY-DRUG CONJUGATES AND METHODS OF USE ZYMEWORKS BC INC. (CA) 2021-11-11 US disclosed
US-11147886-B2 Drug-conjugated bi-specific antigen-binding constructs ZYMEWORKS INC. (CA) 2021-10-19 US disclosed
CN-106794259-B Method of conjugating peptides or proteins using an agent comprising a leaving group comprising a PEG moiety 宝力泰锐克斯有限公司 2021-07-16 CN disclosed
US-20210170023-A1 METHODS OF USING A BISPECIFIC ANTIGEN-BINDING CONSTRUCT TARGETING HER2 IN COMBINATION WITH CDK4/6 INHIBITORS FOR THE TREATMENT OF BREAST CANCER ZYMEWORKS BC INC. (CA) 2021-06-10 US disclosed
US-11000598-B2 Anti-HER2 biparatopic antibody-drug conjugates and methods of use ZYMEWORKS INC. (CA) 2021-05-11 US disclosed
US-10933142-B2 Reversible covalent linkage of functional molecules UCL BUSINESS LTD (GB) 2021-03-02 US disclosed
EP-3765525-A1 ANTI-HER2 BIPARATOPIC ANTIBODY-DRUG CONJUGATES AND METHODS OF USE Zymeworks Inc. (CA) 2021-01-20 EP disclosed
WO-2021003399-A1 ANTI-TISSUE FACTOR ANTIBODY-DRUG CONJUGATES AND RELATED METHODS ICONIC THERAPEUTICS, INC. (US) 2021-01-07 WO disclosed
US-20200392108-A1 ANTIBODY-DRUG CONJUGATES AND RELATED COMPOUNDS, COMPOSITIONS AND METHODS IGENICA BIOTHERAPEUTICS, INC. 2020-12-17 US disclosed
WO-2020242503-A1 METHODS OF USING A BISPECIFIC ANTIGEN-BINDING CONSTRUCT TARGETING HER2 FOR THE TREATMENT OF BILIARY TRACT CANCERS ZYMEWORKS BIOPHARMACEUTICALS INC. (US) 2020-12-03 WO disclosed
CN-111378180-A Force-responsive crosslinked polymer 翁秋梅 2020-07-07 CN disclosed
CN-111378176-A Energy absorption method based on force-induced responsive cross-linked polymer with multiple networks 翁秋梅 2020-07-07 CN disclosed
CN-111378143-A Energy absorption method based on force-induced response supramolecular polymer 翁秋梅 2020-07-07 CN disclosed
CN-111378173-A Force-responsive crosslinked polymer 翁秋梅 2020-07-07 CN disclosed
CN-111378141-A Force-induced response supramolecular polymer 翁秋梅 2020-07-07 CN disclosed
CN-111378171-A Force-responsive crosslinked polymer with multiple networks 翁秋梅 2020-07-07 CN disclosed
CN-111378177-A Energy absorption method based on force-induced responsive polymer with hetero-network structure 翁秋梅 2020-07-07 CN disclosed
CN-111378170-A Force-responsive crosslinked polymer 翁秋梅 2020-07-07 CN disclosed
CN-111378179-A Force-induced response supramolecular polymer 翁秋梅 2020-07-07 CN disclosed
CN-111378140-A Force-induced response supramolecular polymer 翁秋梅 2020-07-07 CN disclosed
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CN-111378182-A Force-induced responsive polymer with single-hybrid network structure 翁秋梅 2020-07-07 CN disclosed
CN-111378178-A Energy absorption method based on force-induced response polymer 翁秋梅 2020-07-07 CN disclosed
CN-111378137-A Force-induced responsive polymer with multi-network structure 翁秋梅 2020-07-07 CN disclosed
CN-111378145-A Force-induced response multiphase supramolecular block polymer 翁秋梅 2020-07-07 CN disclosed
CN-111378144-A Force-induced response supramolecular polymer 翁秋梅 2020-07-07 CN disclosed
CN-111378169-A Force-induced response hybrid crosslinked dynamic polymer 翁秋梅 2020-07-07 CN disclosed
CN-111378139-A Force-induced response supramolecular polymer 翁秋梅 2020-07-07 CN disclosed
CN-111378174-A Force-induced responsive polymer with multi-network cross-linked structure 翁秋梅 2020-07-07 CN disclosed
CN-111378181-A Force-induced responsive polymer with single-hybrid network structure 翁秋梅 2020-07-07 CN disclosed
CN-111378172-A Force-induced responsive polymer with multi-hybrid network structure 翁秋梅 2020-07-07 CN disclosed
CN-111378142-A Force-induced response supramolecular polymer 翁秋梅 2020-07-07 CN disclosed
CN-111378175-A Force-induced response polymer with cross-linked structure 翁秋梅 2020-07-07 CN disclosed
CN-111253610-A Dynamic polymer foam composite material 翁秋梅 2020-06-09 CN disclosed
CN-111218021-A Vitrified dilatant polymer foam hybrid material 翁秋梅 2020-06-02 CN disclosed
CN-111171364-A Force-responsive polymer foam particle and preparation method thereof 翁秋梅 2020-05-19 CN disclosed
CN-111171365-A Force-responsive polymer foam composite material 翁秋梅 2020-05-19 CN disclosed
CN-111166031-A Dilatancy nature electronic product protective sheath/shell 翁秋梅 2020-05-19 CN disclosed
CN-111171330-A Force-responsive dilatancy polymer and method for realizing dilatancy 翁秋梅 2020-05-19 CN disclosed
CN-111150196-A Electronic device package containing dilatant component 翁秋梅 2020-05-15 CN disclosed
CN-111150173-A Shock attenuation sole and shock attenuation shoes 翁秋梅 2020-05-15 CN disclosed
CN-111134409-A Self-adaptive clothes 翁秋梅 2020-05-12 CN disclosed
CN-111040110-A Force-induced response dynamic polymer and application thereof 翁秋梅 2020-04-21 CN disclosed
CN-111040204-A Force-induced response dynamic polymer and application thereof 翁秋梅 2020-04-21 CN disclosed
US-20200108150-A1 REVERSIBLE COVALENT LINKAGE OF FUNCTIONAL MOLECULES UCL BUSINESS LTD (GB) 2020-04-09 US disclosed
US-20200108152-A1 ANTI-HER2 BIPARATOPIC ANTIBODY-DRUG CONJUGATES AND METHODS OF USE ZYMEWORKS BC INC. (CA) 2020-04-09 US disclosed
US-10548982-B2 Reversible covalent linkage of functional molecules UCL BUSINESS LTD (GB) 2020-02-04 US disclosed
WO-2019173911-A1 ANTI-HER2 BIPARATOPIC ANTIBODY-DRUG CONJUGATES AND METHODS OF USE ZYMEWORKS INC. (CA) 2019-09-19 WO disclosed
US-10294205-B2 Allenamide as an orthogonal handle for selective modification of cysteine in peptides and proteins NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2019-05-21 US disclosed
US-20190142950-A1 Reversible Covalent Linkage of Functional Molecules UCL BUSINESS LTD (GB) 2019-05-16 US disclosed
US-10174094-B2 Reversible covalent linkage of functional molecules UCL BUSINESS PLC (GB) 2019-01-08 US disclosed
US-20180193477-A1 DRUG-CONJUGATED BI-SPECIFIC ANTIGEN-BINDING CONSTRUCTS ZYMEWORKS BC INC. (CA) 2018-07-12 US disclosed
US-20180147294-A1 ANTIBODY-DRUG CONJUGATES, COMPOSITIONS AND METHODS OF USE IGENICA BIOTHERAPEUTICS, INC. 2018-05-31 US disclosed
EP-3322735-A1 DRUG-CONJUGATED BI-SPECIFIC ANTIGEN-BINDING CONSTRUCTS Zymeworks Inc. (CA) 2018-05-23 EP disclosed
WO-2017161206-A1 CONJUGATES CONTAINING CONDITIONALLY ACTIVE ANTIBODIES OR ANTIGEN-BINDING FRAGMENTS THEREOF, AND METHODS OF USE HALOZYME, INC. (US) 2017-09-21 WO disclosed
US-9717790-B2 Sphingoglycolipid analogues VICTORIA LINK LIMITED (NZ) 2017-08-01 US disclosed
EP-2365969-B1 Novel anti-biofilm agents YISSUM RES DEV CO (IL) 2017-03-22 EP disclosed
EP-3131875-A1 ALLENAMIDE AS AN ORTHOGONAL HANDLE FOR SELECTIVE MODIFICATION OF CYSTEINE IN PEPTIDES AND PROTEINS Nanyang Technological University (SG) 2017-02-22 EP disclosed
CN-106414397-A Allenamide as an orthogonal handle for selective modification of cysteine in peptides and proteins 南洋理工大学 2017-02-15 CN disclosed
US-20170029373-A1 ALLENAMIDE AS AN ORTHOGONAL HANDLE FOR SELECTIVE MODIFICATION OF CYSTEINE IN PEPTIDES AND PROTEINS NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2017-02-02 US disclosed
WO-2017008169-A1 DRUG-CONJUGATED BI-SPECIFIC ANTIGEN-BINDING CONSTRUCTS ZYMEWORKS INC. (CA) 2017-01-19 WO disclosed
US-20160303247-A1 Antibody-Drug Conjugates and Related Compounds, Compositions, and Methods IGENICA BIOTHERAPEUTICS, INC. (US) 2016-10-20 US disclosed
EP-3044236-A2 MODIFIED ANTI-EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODIES AND METHODS OF USE THEREOF Halozyme, Inc. (US) 2016-07-20 EP disclosed
US-20160176942-A1 Reversible Covalent Linkage of Functional Molecules UCL BUSINESS PLC (GB) 2016-06-23 US disclosed
US-20160136267-A1 SPHINGOGLYCOLIPID ANALOGUES VICTORIA LINK LIMITED (NZ) 2016-05-19 US disclosed
US-9295729-B2 Reversible covalent linkage of functional molecules UCL BUSINESS PLC (GB) 2016-03-29 US disclosed
WO-2015160307-A1 ALLENAMIDE AS AN ORTHOGONAL HANDLE FOR SELECTIVE MODIFICATION OF CYSTEINE IN PEPTIDES AND PROTEINS NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2015-10-22 WO disclosed
CN-104822656-A Self-stabilizing linker conjugates SEATTLE GENETICS INC 2015-08-05 CN disclosed
EP-2889624-A2 Reversible covalent linkage of functional molecules UCL Business PLC (GB) 2015-07-01 EP disclosed
WO-2015038984-A2 MODIFIED ANTI-EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODIES AND METHODS OF USE THEREOF HALOZYME, INC. (US) 2015-03-19 WO disclosed
US-20150071923-A1 MODIFIED ANTI-EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODIES AND METHODS OF USE THEREOF HALOZYME, INC. 2015-03-12 US disclosed
EP-2549276-B1 Reversible covalent linkage of functional molecules UCL BUSINESS PLC (GB) 2015-02-25 EP disclosed
WO-2014200363-A1 SPHINGOGLYCOLIPID ANALOGUES VICTORIA LINK LIMITED (NZ) 2014-12-18 WO disclosed
US-20140363454-A1 Antibody-Drug Conjugates, Compositions and Methods of Use IGENICA BIOTHERAPEUTICS, INC. (US) 2014-12-11 US disclosed
WO-2014197871-A2 ANTIBODY-DRUG CONJUGATES, COMPOSITIONS AND METHODS OF USE IGENICA BIOTHERAPEUTICS, INC. (US) 2014-12-11 WO disclosed
EP-2793585-A1 ANTIBODY-DRUG CONJUGATES AND RELATED COMPOUNDS, COMPOSITIONS, AND METHODS Igenica Biotherapeutics, Inc. (US) 2014-10-29 EP disclosed
US-8865909-B2 Anti-biofilm agents YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2014-10-21 US disclosed
EP-2464654-B1 THIOL PROTECTING GROUP UCL BUSINESS PLC (GB) 2014-10-08 EP disclosed
US-20130224228-A1 Antibody-Drug Conjugates and Related Compounds, Compositions, and Methods IGENICA, INC. (US) 2013-08-29 US disclosed
WO-2013085925-A1 ANTIBODY-DRUG CONJUGATES AND RELATED COMPOUNDS, COMPOSITIONS, AND METHODS IGENICA, INC. (US) 2013-06-13 WO disclosed
EP-2549276-A2 Reversible covalent linkage of functional molecules UCL Business PLC (GB) 2013-01-23 EP disclosed
US-20120190814-A1 Thiol Protecting Group UCL BUSINESS PLC (GB) 2012-07-26 US disclosed
US-20120190579-A1 Functionalisation of Solid Substrates UCL BUSINESS PLC (GB) 2012-07-26 US disclosed
US-20120190124-A1 Reversible Covalent Linkage of Functional Molecules UCL BUSINESS LTD (GB) 2012-07-26 US disclosed
EP-2464654-A2 THIOL PROTECTING GROUP UCL Business PLC (GB) 2012-06-20 EP disclosed
EP-2464972-A1 REVERSIBLE COVALENT LINKAGE OF FUNCTIONAL MOLECULES UCL Business PLC (GB) 2012-06-20 EP disclosed
EP-2464974-A1 FUNCTIONALISATION OF SOLID SUBSTRATES UCL Business PLC (GB) 2012-06-20 EP disclosed
US-20110281921-A1 NOVEL ANTI-BIOFILM AGENTS HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. (IL) 2011-11-17 US disclosed
EP-2365969-A1 Novel anti-biofilm agents Yissum Research Development Company of The Hebrew University of Jerusalem (IL) 2011-09-21 EP disclosed
US-8013603-B2 NMR-detecting cell, NMR-measuring method, and NMR-measuring apparatus JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (JP) 2011-09-06 US disclosed
US-7960380-B2 Non-anilinic derivatives of isothiazol-3(2H)-one 1,1-dioxides as liver X receptor modulators ASTRAZENECA AB (SE) 2011-06-14 US disclosed
WO-2011018611-A1 REVERSIBLE COVALENT LINKAGE OF FUNCTIONAL MOLECULES UCL BUSINESS PLC (GB) 2011-02-17 WO disclosed
WO-2011018613-A1 FUNCTIONALISATION OF SOLID SUBSTRATES UCL BUSINESS PLC (GB) 2011-02-17 WO disclosed
WO-2011018612-A2 THIOL PROTECTING GROUP UCL BUSINESS PLC (GB) 2011-02-17 WO disclosed
US-7887837-B2 conjugate of adenosine diphosphate encapsulated in lipid in vesicle, linker, and substance that recognizes activated platelet and/or an injury site of blood vessel; platelet aggregation inducers Takeoka, Shinji (JP) 2011-02-15 US disclosed
US-20100264919-A1 NMR-Detecting Cell, NMR-Measuring Method, and NMR-Measuring Apparatus JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (JP) 2010-10-21 US disclosed
US-20100227847-A1 Non-Anilinic Derivatives Of Isothiazol-3(2H)-one 1,1-Dioxides As Liver X Receptor Modulators ASTRAZENECA AB (SE) 2010-09-09 US disclosed
WO-2010058402-A1 NOVEL ANTI-BIOFILM AGENTS YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2010-05-27 WO disclosed
US-7723333-B2 Non-anilinic derivatives of isothiazol-3(2H)-one 1,1-dioxides as liver X receptor modulators ASTRAZENECA AB (SE) 2010-05-25 US disclosed
US-20100016321-A1 DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATOR ASTRAZENECA AB (SE) 2010-01-21 US disclosed
US-20090220422-A1 Drug Delivery Material KEIO UNIVERSITY (JP) 2009-09-03 US disclosed
US-7582629-B2 Derivatives of isothiazol-3(2H)-one 1,1-dioxides as liver X receptor modulators ASTRAZENECA AB (SE) 2009-09-01 US disclosed
CN-100478340-C Pyrrole-2, 5-dithione derivatives as liver X receptor modulators ASTRAZENECA AB (SE) 2009-04-15 CN disclosed
CN-100478340-C Pyrrole-2, 5-dithione derivatives as liver X receptor modulators ASTRAZENECA AB (SE) 2009-04-15 CN disclosed
US-20090029945-A2 Non-Anilinic Derivatives of Isothiazol-3(2H)-Thione 1,1-Dioxides As Liver X Receptor Modulators ASTRAZENECA AB (SE) 2009-01-29 US disclosed
US-20090005353-A1 Non-Anilinic Derivatives of Isothiazol-3(2H)-one 1,1-Dioxides as Liver X Receptor Modulators ASTRAZENECA AB (SE) 2009-01-01 US disclosed
US-20080319017-A2 Non-Anilinic Derivatives of Isothiazol-3(2H)-Thione 1,1-Dioxides As Liver X Receptor Modulators ASTRAZENECA AB (SE) 2008-12-25 US disclosed
US-20080255122-A1 Derivatives of Isothiazol-3(2H)-One 1,1-Dioxides as Liver X Receptor Modulators ASTRAZENECA AB (SE) 2008-10-16 US disclosed
EP-1977766-A1 DRUG DELIVERY MATERIAL Keio University (JP) 2008-10-08 EP disclosed
EP-1646625-B1 PYRROLE-2, 5-DITHIONE DERIVATIVES AS LIVER X RECEPTOR MODULATORS ASTRAZENECA AB (SE) 2008-07-02 EP disclosed
US-20080139616-A1 Atherosclerosis; inflammatory diseases, Alzheimer's disease, dyslipidemia, metabolic syndrome; 2-isopropyl-5-phenyl-4-[(4-phenylbutyl)amino]isothiazole-3(2H)-thione 1,1-dioxide for example ASTRAZENECA AB (SE) 2008-06-12 US disclosed
US-20080125396-A1 Derivatives of Isothiazol-3(2H)-Thione 1,1-Dioxides as Liver X Receptor Modulators ATRAZENECA AB (SE) 2008-05-29 US disclosed
CN-101137629-A Non-anilinic derivatives of isothiazol-3(2h)-thione 1,1-dioxides as liver x receptor modulators ASTRAZENECA AB (SE) 2008-03-05 CN disclosed
CN-101137628-A Non-anilinic derivatives of isothiazol-3(2h)-one 1,1-dioxides as liver x receptor modulators ASTRAZENECA AB (SE) 2008-03-05 CN disclosed
CN-101137630-A Non-anilinic derivatives of isothiazol-3(2h)-thione 1,1-dioxides as liver x receptor modulators ASTRAZENECA AB (SE) 2008-03-05 CN disclosed
CN-100360554-C peptide conjugates UNIV KEIO (JP) 2008-01-09 CN disclosed
CN-101098861-A Aniline derivatives of isothiazol-3 (2H) -thione 1, 1-dioxides as liver X receptor modulators ASTRAZENECA AB (SE) 2008-01-02 CN disclosed
EP-1838687-A1 NON-ANILINIC DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS AstraZeneca AB (SE) 2007-10-03 EP disclosed
EP-1838685-A1 DERIVATIVES OF ISOTHIAZOL-3 (2H)-THIONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS AstraZeneca AB (SE) 2007-10-03 EP disclosed
EP-1838686-A1 DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS AstraZeneca AB (SE) 2007-10-03 EP disclosed
EP-1262490-B1 GPib-LIPID BOND CONSTRUCT AND USE THEREOF MITSUBISHI PHARMA CORP (JP) 2007-10-03 EP disclosed
EP-1838684-A1 NON-ANILINIC DERIVATIVES OF ISOTHIAZOL-3(2H)-THIONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS AstraZeneca AB (SE) 2007-10-03 EP disclosed
US-20070059376-A1 Peptide conjugate KEIO UNIVERSITY (JP) 2007-03-15 US disclosed
US-20060189663-A1 Pyrrole-2,5-dithione derivatives as liver x receptor modulators ASTRAZENECA AB (SE) 2006-08-24 US disclosed
US-20060189663-A1 Pyrrole-2,5-dithione derivatives as liver x receptor modulators ASTRAZENECA AB (SE) 2006-08-24 US disclosed
CN-1820003-A Pyrrole-2, 5-dithione derivatives as liver X receptor modulators ASTRAZENECA AB (SE) 2006-08-16 CN disclosed
CN-1820003-A Pyrrole-2, 5-dithione derivatives as liver X receptor modulators ASTRAZENECA AB (SE) 2006-08-16 CN disclosed
WO-2006073364-A1 DERIVATIVES OF ISOTHIAZOL-3 (2H)-THIONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS ASTRAZENECA AB (SE) 2006-07-13 WO disclosed
WO-2006073365-A1 NON-ANILINIC DERIVATIVES OF ISOTHIAZOL-3(2H)-THIONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS ASTRAZENECA AB (SE) 2006-07-13 WO disclosed
WO-2006073366-A1 NON-ANILINIC DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS ASTRAZENECA AB (SE) 2006-07-13 WO disclosed
WO-2006073363-A1 DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS ASTRAZENECA AB (SE) 2006-07-13 WO disclosed
EP-1646625-A1 PYRROLE-2, 5-DITHIONE DERIVATIVES AS LIVER X RECEPTOR MODULATORS AstraZeneca AB (SE) 2006-04-19 EP disclosed
CN-1747967-A Peptide conjugate UNIV KEIO (JP) 2006-03-15 CN disclosed
EP-1591451-A1 PEPTIDE CONJUGATE Keio University (JP) 2005-11-02 EP disclosed
US-6926884-B2 GPIb-lipid bond construct and use thereof MITSUBISHI PHARMA CORPORATION (JP) 2005-08-09 US disclosed
WO-2005005416-A1 PYRROLE-2, 5-DITHIONE DERIVATIVES AS LIVER X RECEPTOR MODULATORS ASTRAZENECA AB (SE) 2005-01-20 WO disclosed
US-20030113262-A1 Gpib-lipid bond construct and use thereof IKEDA, YASUO (JP) 2003-06-19 US disclosed
EP-1262490-A1 GPib-LIPID BOND CONSTRUCT AND USE THEREOF Mitsubishi Pharma Corporation (JP) 2002-12-04 EP disclosed
US-6177059-B1 DRUGS AND COMPLEXES WITH LIPIDS YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 2001-01-23 US disclosed
EP-0894807-A1 GPIb-LIPID COMPLEX AND USES THEREOF YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1999-02-03 EP disclosed
EP-0894807-A1 GPIb-LIPID COMPLEX AND USES THEREOF YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 1999-02-03 EP disclosed