⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethyl Sulfone SCHEMBL169867 | 0.93 | KDM4E (1.00) | — | |
| Dimethyl Sulfone SCHEMBL19382 | 0.93 | — | — | |
| Dimethyl Sulfone SCHEMBL31274688 | 0.86 | — | — | |
| Dimethyl Sulfone SCHEMBL5075879 | 0.86 | — | — | |
| Dimethyl Sulfone SCHEMBL31663999 | 0.86 | — | — | |
| Dimethyl Sulfone SCHEMBL23036991 | 0.86 | — | — | |
| Dimethyl Sulfone SCHEMBL4580403 | 0.86 | — | — | |
| Dimethyl Sulfone SCHEMBL11761411 | 0.86 | — | — | |
| Dimethyl Sulfone SCHEMBL3142511 | 0.86 | — | — | |
| Dimethyl Sulfone SCHEMBL31009021 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10919855-B2 | Process to prepare n-[2-[(1s)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulphonyl) ethyl]-1, 3-dioxo-2,3-dihydro-1h-isoindol-4yl]acetamide | UNICHEM LABORATORIES LTD (IN) | 2021-02-16 | — | — | US | disclosed |
| US-20200181085-A1 | NOVEL PROCESS TO PREPARE N-[2-[(1S)-1-(3-ETHOXY-4-METHOXYPHENYL)-2-(METHYLSULPHONYL) ETHYL]-1, 3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-4-YL]ACETAMIDE | UNICHEM LABORATORIES LTD (IN) | 2020-06-11 | — | — | US | disclosed |
| EP-3619195-A1 | NOVEL PROCESS TO PREPARE N-[2-[(1S)-1-(3-ETHOXY-4-METHOXYPHENYL)-2-(METHYLSULPHONYL) ETHYL]-1, 3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-4-YL]ACETAMIDE | Unichem Laboratories Ltd (IN) | 2020-03-11 | — | — | EP | disclosed |
| US-10287248-B2 | Process for the preparation of apremilast | CIPLA LIMITED (IN) | 2019-05-14 | — | — | US | disclosed |
| CN-106008313-B | Substituted -1,3 derovatives of isoindoline | 康塞特医药品有限公司 | 2018-11-13 | — | — | CN | disclosed |
| WO-2018203192-A1 | NOVEL PROCESS TO PREPARE N-[2-[(1S)-1-(3-ETHOXY-4-METHOXYPHENYL)-2-(METHYLSULPHONYL) ETHYL]-1, 3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-4-YL]ACETAMIDE | UNICHEM LABORATORIES LTD (IN) | 2018-11-08 | — | — | WO | disclosed |
| US-20180237390-A1 | IMPROVED PROCESS FOR THE PREPARATION OF APREMILAST | CIPLA LIMITED (IN) | 2018-08-23 | — | — | US | disclosed |
| CN-105633388-B | The cathode of battery based on sulphur | 通用汽车环球科技运作有限责任公司 | 2018-04-24 | — | — | CN | disclosed |
| CN-107635962-A | Improved process for preparing apremilast | 印度商西伯拉有限公司 | 2018-01-26 | — | — | CN | disclosed |
| EP-3271330-A1 | IMPROVED PROCESS FOR THE PREPARATION OF APREMILAST | Cipla Limited (IN) | 2018-01-24 | — | — | EP | disclosed |
| US-8883843-B2 | Substituted isoindoline-1,3-dione derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2014-11-11 | — | — | US | disclosed |
| EP-2443089-B1 | DEUTERATED ISOINDOLINE-1,3-DIONE DERIVATIVES AS PDE4 AND TNF-ALPHA INHIBITORS | CONCERT PHARMACEUTICALS INC (US) | 2014-03-05 | — | — | EP | disclosed |
| EP-2690092-A1 | Deuterated isoindoline-1,3-dione derivatives as PDE4 and TNF-alpha inhibitors | Concert Pharmaceuticals Inc. (US) | 2014-01-29 | — | — | EP | disclosed |
| US-20130345282-A1 | SUBSTITUTED ISOINDOLINE-1,3-DIONE DERIVATIVES | CONCERT PHARMACEUTICALS, INC. (US) | 2013-12-26 | — | — | US | disclosed |
| US-8404737-B2 | Substituted isoindoline-1,3-dione derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2013-03-26 | — | — | US | disclosed |
| US-20120252864-A1 | SUBSTITUTED ISOINDOLINE-1,3-DIONE DERIVATIVES | CONCERT PHARMACEUTICALS INC. | 2012-10-04 | — | — | US | disclosed |
| EP-2443089-A1 | DEUTERATED I SOINDOLINE- I, 3-DIONE DERIVATIVES AS PDE4 AND TNF-ALPHA INHIBITORS | Concert Pharmaceuticals Inc. (US) | 2012-04-25 | — | — | EP | disclosed |
| US-8124646-B2 | Substituted isoindoline-1,3-dione derivatives | CONCERT PHARMACEUTICALS, INC. (US) | 2012-02-28 | — | — | US | disclosed |
| US-20100324108-A1 | SUBSTITUTED ISOINDOLINE-1,3-DIONE DERIVATIVES | CONCERT PHARMACEUTICALS INC. | 2010-12-23 | — | — | US | disclosed |
| WO-2010147922-A1 | DEUTERATED I SOINDOLINE- I, 3-DIONE DERIVATIVES AS PDE4 AND TNF-ALPHA INHIBITORS | CONCERT PHARMACEUTICALS, INC. (US) | 2010-12-23 | — | — | WO | disclosed |