Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 5/20 | 1.00 |
| ▸ | KDR | P35968 | 8/20 | 0.77 |
| ▸ | PDGFRB | P09619 | 6/20 | 0.77 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.77 |
| ▸ | RET | P07949 | 4/20 | 0.77 |
| ▸ | FLT1 | P17948 | 3/20 | 0.77 |
| ▸ | JAK3 | P52333 | 3/20 | 0.77 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.77 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.77 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.77 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.77 |
| ▸ | LCK | P06239 | 2/20 | 0.77 |
| ▸ | CSF1R | P07333 | 2/20 | 0.77 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.77 |
| ▸ | LTK | P29376 | 2/20 | 0.77 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.77 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.77 |
| ▸ | MST1R | Q04912 | 2/20 | 0.77 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.77 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6859929 | 1.00 | CHEK1 (1.00) | CHEK1KDRPDGFRBAURKBRET | |
| SCHEMBL6859928 | 1.00 | CHEK1 (1.00) | CHEK1KDRPDGFRBAURKBRET | |
| SCHEMBL5728571 | 0.87 | PDPK1 (1.00) | CHEK1KDRPDGFRBAURKBRET | |
| SCHEMBL5728570 | 0.87 | PDPK1 (1.00) | CHEK1KDRPDGFRBAURKBRET | |
| SCHEMBL6671402 | 0.86 | CHEK1 (0.76) | CHEK1KDRPDGFRBAURKBRET | |
| SCHEMBL6671398 | 0.86 | CHEK1 (0.76) | CHEK1KDRPDGFRBAURKBRET | |
| SCHEMBL19691 | 0.80 | PDPK1 (1.00) | CHEK1KDRPDGFRBAURKBRET | |
| SCHEMBL19692 | 0.80 | PDPK1 (1.00) | CHEK1KDRPDGFRBAURKBRET | |
| SCHEMBL6674605 | 0.78 | CHEK1 (1.00) | CHEK1KDRPDGFRBAURKBRET | |
| SCHEMBL31061315 | 0.78 | CHEK1 (1.00) | CHEK1KDRPDGFRBAURKBRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030162785-A1 | Protein kinase inhibitors | ABBVIE INC. | 2003-08-28 | — | — | US | claimed |
| US-20030119839-A1 | Protein kinase inhibitors | ABBOTT LABORATORIES | 2003-06-26 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030162785-A1 | Protein kinase inhibitors | MAP3K20, MAP3K1, MAP3K6 | CHEK1 139/4885KDR 1241/4885PDGFRB 766/4885 |
| US-20030119839-A1 | Protein kinase inhibitors | MAP3K20, MAP3K1, MAP3K6 | CHEK1 139/4885KDR 1241/4885PDGFRB 766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.