Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 15/20 | 1.00 |
| ▸ | PPARA | Q07869 | 7/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.50 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7040832 | 0.90 | PPARG (0.81) | PPARGPPARAMEN1POLBKMT2A | |
| SCHEMBL7034817 | 0.89 | PPARG (0.80) | PPARGPPARAMEN1POLBKMT2A | |
| SCHEMBL7034829 | 0.89 | PPARG (0.80) | PPARGPPARAMEN1POLBKMT2A | |
| Lithium Ion SCHEMBL7041189 | 0.87 | PPARG (0.77) | PPARGPPARA | |
| Lithium Ion SCHEMBL7038553 | 0.83 | PPARG (0.72) | PPARGPPARAMEN1POLBKMT2A | |
| Lithium Ion SCHEMBL7041701 | 0.83 | PPARG (0.71) | PPARGPPARAMEN1POLBKMT2A | |
| Lithium Ion SCHEMBL7039324 | 0.83 | PPARG (0.84) | PPARGPPARAMEN1POLBKMT2A | |
| Lithium Ion SCHEMBL7151915 | 0.82 | PPARG (0.69) | PPARGPPARATP53NPC1 | |
| Lithium Ion SCHEMBL7038128 | 0.82 | PPARG (0.69) | PPARGPPARA | |
| Lithium Ion SCHEMBL7040492 | 0.81 | PPARG (1.00) | PPARGPPARAMEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030073862-A1 | Compounds | BIOVITRUM AB (SE) | 2003-04-17 | — | — | US | disclosed |
| WO-2003004458-A1 | NEW COMPOUNDS | BIOVITRUM AB (SE) | 2003-01-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030073862-A1 | Compounds | PPARG, PPARA, PPARD | PPARG 1/4885PPARA 2/4885MEN1 4333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.