Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 18/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.51 |
| ▸ | PDE6C | P51160 | 2/20 | 0.51 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.51 |
| ▸ | PDE2A | O00408 | 1/20 | 0.51 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.51 |
| ▸ | PDE6D | O43924 | 1/20 | 0.51 |
| ▸ | PDE8A | O60658 | 1/20 | 0.51 |
| ▸ | PDE9A | O76083 | 1/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | PDE6A | P16499 | 1/20 | 0.51 |
| ▸ | PDE6G | P18545 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | PDE6B | P35913 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7027345 | 0.85 | PDE5A (0.51) | PDE5APDE3BPDE3APDE6CABCC4 | |
| SCHEMBL7003278 | 0.84 | PDE5A (0.71) | PDE5APDE3BPDE3APDE6CABCC4 | |
| SCHEMBL6715447 | 0.83 | PDE5A (0.74) | PDE5APDE3BPDE3APDE6CABCC4 | |
| SCHEMBL22539815 | 0.79 | KMT2A (0.49) | PDE5APDE3BPDE3APDE6CABCC4 | |
| SCHEMBL6713800 | 0.79 | KMT2A (0.61) | PDE5APDE3BPDE3APDE6CABCC4 | |
| SCHEMBL6716951 | 0.79 | PDE5A (0.75) | PDE5APDE3BPDE3APDE6CABCC4 | |
| SCHEMBL6716451 | 0.79 | PDE5A (0.66) | PDE5APDE3BPDE3APDE6CPDE4A | |
| SCHEMBL23370666 | 0.78 | KMT2A (0.66) | PDE5APDE3BPDE3APDE6CABCC4 | |
| SCHEMBL6715415 | 0.77 | PDE5A (0.63) | PDE5APDE3BPDE3APDE6CABCC4 | |
| SCHEMBL6719165 | 0.77 | PDE5A (0.74) | PDE5APDE3BPDE3APDE6CABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395593-A4 | NOVEL PYRAZOLOPYRIMIDINETHIONE DERIVATIVES. PREPARATION METHODS THEREOF AND THEIR USE AS THERAPEUTICS FOR ERECTILE DYSFUNCTION | KOREA INST SCI & TECH (KR) | 2004-11-10 | — | — | EP | disclosed |
| EP-1395593-A1 | NOVEL PYRAZOLOPYRIMIDINETHIONE DERIVATIVES. PREPARATION METHODS THEREOF AND THEIR USE AS THERAPEUTICS FOR ERECTILE DYSFUNCTION | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2004-03-10 | — | — | EP | disclosed |
| WO-2002102802-A1 | NOVEL PYRAZOLOPYRIMIDINETHIONE DERIVATIVES. PREPARATION METHODS THEREOF AND THEIR USE AS THERAPEUTICS FOR ERECTILE DYSFUNCTION | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2002-12-27 | — | — | WO | disclosed |