Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 7/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | UBE2N | P61088 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LIPE | Q05469 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7036016 | 1.00 | KDM4E (0.49) | KDM4ELMNAAPPAKR1C3POLB | |
| SCHEMBL27396919 | 0.88 | POLB (0.47) | KDM4ELMNAAPPPOLBUBE2N | |
| SCHEMBL7646409 | 0.84 | FFAR4 (0.51) | KDM4ELMNAAPPAKR1C3LCK | |
| SCHEMBL7113088 | 0.84 | FFAR4 (0.51) | KDM4ELMNAAPPAKR1C3LCK | |
| SCHEMBL3271115 | 0.82 | APP (0.65) | KDM4ELMNAAPPPOLBSMN1; SMN2 | |
| SCHEMBL14205236 | 0.82 | KDM4E (0.52) | KDM4ELMNAAPPAKR1C3RAB9A | |
| SCHEMBL15963939 | 0.82 | APP (0.58) | KDM4ELMNAAPPPOLBSMN1; SMN2 | |
| SCHEMBL29529587 | 0.82 | APP (0.65) | KDM4ELMNAAPPPOLBSMN1; SMN2 | |
| SCHEMBL14763980 | 0.82 | APP (0.65) | KDM4ELMNAAPPPOLBSMN1; SMN2 | |
| SCHEMBL891624 | 0.82 | APP (0.65) | KDM4ELMNAAPPPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0659737-B1 | Catecholamine surrogates useful as beta 3 agonists | BRISTOL MYERS SQUIBB CO (US) | 2003-03-26 | — | — | EP | disclosed |
| EP-0659737-A2 | Catecholamine surrogates useful as B3 agonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-06-28 | — | — | EP | disclosed |